S100A12

Gene Symbol	S100A12
Entrez Gene	6283
Alt Symbol	CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6
Species	Human
Gene Type	protein-coding
Description	S100 calcium binding protein A12
Other Description	EN-RAGE|S100 calcium-binding protein A12 (calgranulin C)|calcitermin|calcium-binding protein in amniotic fluid 1|calgranulin C|calgranulin-C|extracellular newly identified RAGE-binding protein|migration inhibitory factor-related protein 6|neutrophil S100 protein|protein S100-A12
Swissprots	P83219 P80511 Q7M4R1 Q5SY66
Accessions	BAA12030 CAB94792 EAW53332 P80511 BC070294 AAH70294 D49549 BAA08497 D83664 BAA12036 HQ257882 ADR82637 X97859 CAA66453 NM_005621 NP_005612
Function	S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+)
Subcellular Location	Secreted {ECO:0000269|PubMed:22811950}. Cytoplasm {ECO:0000269|PubMed:22811950}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22811950}. Cell membrane {ECO:0000269|PubMed:22811950}; Peripheral membrane protein {ECO:0000269|PubMed:22811950}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
Tissue Specificity	Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human S100A12 ELISA Kit (Sandwich ELISA) - LS-F4417 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 78 pg/ml Range 78-5000 pg/ml

Human S100A12 ELISA Kit (Sandwich ELISA) - LS-F12541 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 pg/ml Range 78-5000 pg/ml

Protein S100-A12, S100A12, Human, ELISA Kit - E1504h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 pg/mL

S100 calcium binding protein A12/Calgranulin-C (S100A12), Human, ELISA Kit - CSB-E13095h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.12ng/ml Range 12.5 ng/ml-800 ng/ml

S100 Calcium Binding Protein A12, S100A12, Human, ELISA Kit - E-EL-H1293 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

S100 Calcium Binding Protein A12, S100A12, Rabbit, ELISA Kit - E-EL-RB2146 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

S100 Calcium Binding Protein A12, S100A12, Chicken, ELISA Kit - E-EL-Ch1054 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

S100 Calcium Binding Protein A12, S100A12, Porcine, ELISA Kit - E-EL-P1122 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

S100 Calcium Binding Protein A12, S100A12, Guinea Pig, ELISA Kit - E-EL-GP0461 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

S100 Calcium Binding Protein A12, S100A12, Monkey, ELISA Kit - E-EL-MK0748 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human S100A12 ELISA Kit - HS0031 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine S100A12 ELISA Kit - AS0031 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

S100 Calcium Binding Protein A12, ELISA Kit - MBS738642 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

S100 Calcium Binding Protein A12, ELISA Kit - MBS740961 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

S100 Calcium Binding Protein A12, ELISA Kit - MBS731260 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive) Sensitivity 1.0 pg/mL.

S100 Calcium Binding Protein A12, ELISA Kit - MBS733584 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

S100 Calcium Binding Protein A12, ELISA Kit - MBS735390 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

S100 Calcium Binding Protein A12, ELISA Kit - MBS728991 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

S100 Calcium Binding Protein A12, ELISA Kit - MBS734379 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

S100 Calcium Binding Protein A12, ELISA Kit - MBS731072 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

S100 Calcium Binding Protein A12, ELISA Kit - MBS736961 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

S100 Calcium Binding Protein A12, ELISA Kit - MBS725476 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

S100 Calcium Binding Protein A12 (S100A12), ELISA Kit - MBS2020719 from MyBioSource Category ELISA Kit Prices $320.00, $470.00, $630.00, $2,565.00, $4,650.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 30pg/mL. Range 78.13-5000pg/mL

S100 Calcium Binding Protein A12 (S100A12) - MBS9309846 from MyBioSource Category ELISA Kit Prices $435.00, $600.00 Sizes 48 strip wells, 96 strip wells

S100 calcium binding protein A12/Calgranulin-C (S100A12) , ELISA Kit - MBS705801 from MyBioSource Category ELISA Kit Prices $550.00, $795.00, $2,890.00, $5,465.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.156 ng /ml. Range 0.625 ng/ml -40 ng/ml.

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