S100A12

Gene Symbol	S100A12
Entrez Gene	6283
Alt Symbol	CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6
Species	Human
Gene Type	protein-coding
Description	S100 calcium binding protein A12
Other Description	EN-RAGE|S100 calcium-binding protein A12 (calgranulin C)|calcitermin|calcium-binding protein in amniotic fluid 1|calgranulin C|calgranulin-C|extracellular newly identified RAGE-binding protein|migration inhibitory factor-related protein 6|neutrophil S100 protein|protein S100-A12
Swissprots	P83219 P80511 Q7M4R1 Q5SY66
Accessions	BAA12030 CAB94792 EAW53332 P80511 BC070294 AAH70294 D49549 BAA08497 D83664 BAA12036 HQ257882 ADR82637 X97859 CAA66453 NM_005621 NP_005612
Function	S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+)
Subcellular Location	Secreted {ECO:0000269|PubMed:22811950}. Cytoplasm {ECO:0000269|PubMed:22811950}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22811950}. Cell membrane {ECO:0000269|PubMed:22811950}; Peripheral membrane protein {ECO:0000269|PubMed:22811950}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
Tissue Specificity	Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human S100A12 full length protein - ab103393 from Abcam Category Protein Source E. coli Species Human

Recombinant Human EN-RAGE/S100A12 Protein - H00006283-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human EN-RAGE/S100A12 Protein - H00006283-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human EN-RAGE, CF - 1052-ER-050 from R&D Systems Category Protein Source E. coli-derived, Met1-Glu92

S100A12 Protein (OPPA00091) - OPPA00091 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Escherichia Coli.

Human CAAF1 protein - orb83107 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human S100A12 protein - orb169226 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human CAAF1 protein - orb83704 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human CAAF1 protein - orb83205 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human S100A12 Protein - abx068954 from Abbexa Category Protein Source E.coli Species Human

S100A12 - H00006283-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

S100A12 - H00006283-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

S100A12 - H00006283-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

S100A12 - H00006283-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

S100 Calcium Binding Protein A12 (S100A12), Human - 20-7462 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Human

CAGC Recombinant Protein (Mass Spec Standard (C13 and N15-labeled)) - 96-665 from ProSci Category Protein Source HEK293 cells Species Human

S100A12 fusion protein - Ag9961 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

S100A12 Human - PRPS-159 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human S100 Calcium Binding Protein A12 - BP001843-PRO-152 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

S100A12 Human Protein - GWB-BSP636 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human S100 Calcium Binding Protein A12 - S100A12-3096H from Creative Biomart Category Protein Source E.coli.

Recombinant Human S100A12, His-tagged - S100A12-30229TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human S100A12, GST-tagged - S100A12-2483H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human S100A12, Fc-tagged - S100A12-215H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human S100A12, Fc-tagged, C13&N15 Labeled - S100A12-204H from Creative Biomart Category Protein Source HEK293 Species Human

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