| Gene Symbol |
PTH2R
|
| Entrez Gene |
5746
|
| Alt Symbol |
PTHR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
parathyroid hormone 2 receptor
|
| Other Description |
PTH2 receptor|parathyroid hormone receptor 2
|
| Swissprots |
P49190 Q8N429
|
| Accessions |
AAA96796 AAY14871 AAY15091 EAW70451 P49190 AK294181 BAG57499 AK309827 AY497546 AAR90849 BC036811 AAH36811 BM808818 CR747526 DB536374 HQ257935 ADR82689 U25128 AAC50157 XM_011511517 XP_011509819 XR_922972 NM_005048 NP_005039 NR_073601
|
| Function |
This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed abundantly in brain and pancreas. Also expressed in the testis. {ECO:0000269|PubMed:7797535}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|
![Western Blot: Parathyroid Hormone Receptor 2 Overexpression Lysate (Adult Normal) [NBL1-14947] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Parathyroid Hormone Receptor 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1051_Parathyroid%2520Hormone%2520Receptor%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14947-img0002.jpg)