Gene Symbol | PTH2R |
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Entrez Gene | 5746 |
Alt Symbol | PTHR2 |
Species | Human |
Gene Type | protein-coding |
Description | parathyroid hormone 2 receptor |
Other Description | PTH2 receptor|parathyroid hormone receptor 2 |
Swissprots | P49190 Q8N429 |
Accessions | AAA96796 AAY14871 AAY15091 EAW70451 P49190 AK294181 BAG57499 AK309827 AY497546 AAR90849 BC036811 AAH36811 BM808818 CR747526 DB536374 HQ257935 ADR82689 U25128 AAC50157 XM_011511517 XP_011509819 XR_922972 NM_005048 NP_005039 NR_073601 |
Function | This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed abundantly in brain and pancreas. Also expressed in the testis. {ECO:0000269|PubMed:7797535}. |
Top Pathways | Neuroactive ligand-receptor interaction |
PTH2 Receptor CRISPR/Cas9 KO Plasmid (h) - sc-407728 from Santa Cruz Biotechnology
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PTH2 Receptor HDR Plasmid (h) - sc-407728-HDR from Santa Cruz Biotechnology
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PTH2 Receptor Double Nickase Plasmid (h) - sc-407728-NIC from Santa Cruz Biotechnology
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PTH2 Receptor Double Nickase Plasmid (h2) - sc-407728-NIC-2 from Santa Cruz Biotechnology
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PTH2 Receptor CRISPR Activation Plasmid (h) - sc-407728-ACT from Santa Cruz Biotechnology
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PTH2 Receptor CRISPR Activation Plasmid (h2) - sc-407728-ACT-2 from Santa Cruz Biotechnology
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PTH2 Receptor Lentiviral Activation Particles (h) - sc-407728-LAC from Santa Cruz Biotechnology
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PTH2 Receptor Lentiviral Activation Particles (h2) - sc-407728-LAC-2 from Santa Cruz Biotechnology
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PTH2 Receptor siRNA (h) - sc-40156 from Santa Cruz Biotechnology
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PTH2 Receptor shRNA Plasmid (h) - sc-40156-SH from Santa Cruz Biotechnology
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PTH2 Receptor shRNA (h) Lentiviral Particles - sc-40156-V from Santa Cruz Biotechnology
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PTH2R RNAi - H00005746-R02 from Novus Biologicals
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MISSION® esiRNA - EHU004211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17680 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17680 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06965 from Sigma-Aldrich
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PTH2R siRNA (Human) - CRH3888 from Cohesion Biosciences
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Human PTH2R siRNA - orb264390 from Biorbyt
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PTH2R shRNA Plasmid (Human) - CHH3888 from Cohesion Biosciences
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PTH2R miRNA 3'UTR clone - MiUTR1H-08432 from Creative biogene
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