C5AR1

Gene Symbol	C5AR1
Entrez Gene	728
Alt Symbol	C5A, C5AR, C5R1, CD88
Species	Human
Gene Type	protein-coding
Description	complement component 5a receptor 1
Other Description	C5a anaphylatoxin chemotactic receptor 1|C5a anaphylatoxin receptor|C5a ligand|C5a-R|complement component 5 receptor 1
Swissprots	P21730
Accessions	AAD14919 AAO65969 CAB37830 EAW57470 EAW57471 P21730 BC008982 AAH08982 BE042476 BI916506 BM830753 BT007358 AAP36022 DQ891757 ABM82683 DQ894940 ABM85866 M62505 AAA62831 X57250 CAA40530 XM_005259190 XP_005259247 XM_011527247 XP_011525549 NM_001736 NP_001727
Function	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12464600}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269|PubMed:12464600}.
Top Pathways	Complement and coagulation cascades, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

C5AR1 293T Cell Transient Overexpression Lysate(Denatured) - H00000728-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

C5AR1 overexpression lysate - LY400657 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

C5AR1 293 Cell Lysate - 400646 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Complement Component C5a R1 Overexpression Lysate (Denatured) - H00000728-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Complement Component C5a R1 Overexpression Lysate (Native) - NBL1-08482 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CD88 (h): 293 Lysate - sc-110903 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CD88 (h): 293T Lysate - sc-175352 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CD88 (h2): 293T Lysate - sc-175354 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CD88 (h3): 293T Lysate - sc-158362 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

C5AR1 Over-expression Lysate Product - GWB-474560 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Complement Component C5a R1 Overexpression Lysate (Denatured) - H00000728-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human C5AR1 Knockdown Stable Cell Line - CSC-DC002069 from Creative biogene Category Cell Line Species Human

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