| Gene Symbol |
NPLOC4
|
| Entrez Gene |
55666
|
| Alt Symbol |
NPL4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear protein localization 4 homolog (S. cerevisiae)
|
| Other Description |
nuclear protein localization protein 4 homolog
|
| Swissprots |
Q8N3J1 Q9NWR5 Q9H8V2 Q8TAT6 Q9P229 Q9H964
|
| Accessions |
EAW89661 EAW89662 EAW89663 Q8TAT6 AB040932 BAA96023 AK000664 BAA91314 AK023046 BAB14372 AK023272 BAB14499 AK024398 AK074322 AK294473 BAG57700 AK311741 AL133629 AL834300 CAD38971 BC013406 BC025930 AAH25930 BU542911 CK903591 DA998574 DC322260 DQ587272 DQ587568 DQ895356 ABM86282 HY116973 HY179409 XM_011524979 XP_011523281 XM_011524980 XP_011523282 XM_011524981 XP_011523283 XM_011524982 XP_011523284 XR_934501 XR_934502 NM_017921 NP_060391 NR_130139 NR_130140
|
| Function |
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250}.
|
| Tissue Specificity |
Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver. {ECO:0000269|PubMed:11574150}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|