NPLOC4

Gene Symbol NPLOC4
Entrez Gene 55666
Alt Symbol NPL4
Species Human
Gene Type protein-coding
Description nuclear protein localization 4 homolog (S. cerevisiae)
Other Description nuclear protein localization protein 4 homolog
Swissprots Q8N3J1 Q9NWR5 Q9H8V2 Q8TAT6 Q9P229 Q9H964
Accessions EAW89661 EAW89662 EAW89663 Q8TAT6 AB040932 BAA96023 AK000664 BAA91314 AK023046 BAB14372 AK023272 BAB14499 AK024398 AK074322 AK294473 BAG57700 AK311741 AL133629 AL834300 CAD38971 BC013406 BC025930 AAH25930 BU542911 CK903591 DA998574 DC322260 DQ587272 DQ587568 DQ895356 ABM86282 HY116973 HY179409 XM_011524979 XP_011523281 XM_011524980 XP_011523282 XM_011524981 XP_011523283 XM_011524982 XP_011523284 XR_934501 XR_934502 NM_017921 NP_060391 NR_130139 NR_130140
Function The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250}.
Tissue Specificity Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver. {ECO:0000269|PubMed:11574150}.
Top Pathways Protein processing in endoplasmic reticulum

Npl4 CRISPR/Cas9 KO Plasmid (h) - sc-403787 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Npl4 HDR Plasmid (h) - sc-403787-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Npl4 Double Nickase Plasmid (h) - sc-403787-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Npl4 Double Nickase Plasmid (h2) - sc-403787-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Npl4 CRISPR Activation Plasmid (h) - sc-403787-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Npl4 CRISPR Activation Plasmid (h2) - sc-403787-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Npl4 Lentiviral Activation Particles (h) - sc-403787-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Npl4 Lentiviral Activation Particles (h2) - sc-403787-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Npl4 siRNA (h) - sc-61227 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Npl4 shRNA Plasmid (h) - sc-61227-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Npl4 shRNA (h) Lentiviral Particles - sc-61227-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU043731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15459 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15459 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11569 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11569

NPLOC4 siRNA (Human) - CRJ0818 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NPLOC4 (NM_017921.2) - SHH354300 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NPLOC4(NM_017921.2) - SHR018402 from Creative biogene

Category siRNA
Species Reactivities Human

Human NPLOC4 siRNA - orb271319 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NPLOC4 shRNA Plasmid (Human) - CHJ0818 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NPLOC4 miRNA 3'UTR clone - MiUTR1H-06877 from Creative biogene

Species Reactivities Human
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