TMIGD2

Gene Symbol	TMIGD2
Entrez Gene	126259
Alt Symbol	IGPR-1, IGPR1
Species	Human
Gene Type	protein-coding
Description	transmembrane and immunoglobulin domain containing 2
Other Description	CD28 homolog|immunoglobulin and proline-rich receptor 1|immunoglobulin-containing and proline-rich receptor 1|transmembrane and immunoglobulin domain-containing protein 2|transmembrane and immunoglobulin domain-containing protein 2 variant 2|transmembrane and immunoglobulin domain-containing protein 2 variant 3
Swissprots	Q96BF3 Q6UW59
Accessions	EAW69239 EAW69240 Q96BF3 AY358964 AAQ89323 BC015655 AAH15655 BU629751 HQ452865 AED88282 HQ452866 AED88283 HY260382 XM_011527679 XP_011525981 NM_001169126 NP_001162597 NM_001308232 NP_001295161 NM_144615 NP_653216
Function	Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22419821}; Single-pass type I membrane protein {ECO:0000269|PubMed:22419821}.
Tissue Specificity	Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double- negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cel

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TMIGD2-Over-expression-Lysate - LY16086a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

TMIGD2 overexpression lysate - LY408250 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TMIGD2 overexpression lysate - LY432814 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TMIGD2 293 Cell Lysate - 404568 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TMIGD2 Overexpression Lysate (Native) - NBL1-17114 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TMIGD2 Over-expression Lysate Product - GWB-74F56D from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human IGPR-1 / TMIGD2 HEK293 Cell Lysate (WB positive control) - 13820-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IGPR-1 Human Cells Transfected Lysate (positive control) (denatured) - orb232954 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human TMIGD2 Knockdown Stable Cell Line - CSC-DC016301 from Creative biogene Category Cell Line Species Human

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