| Gene Symbol | TMIGD2 |
|---|---|
| Entrez Gene | 126259 |
| Alt Symbol | IGPR-1, IGPR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transmembrane and immunoglobulin domain containing 2 |
| Other Description | CD28 homolog|immunoglobulin and proline-rich receptor 1|immunoglobulin-containing and proline-rich receptor 1|transmembrane and immunoglobulin domain-containing protein 2|transmembrane and immunoglobulin domain-containing protein 2 variant 2|transmembrane and immunoglobulin domain-containing protein 2 variant 3 |
| Swissprots | Q96BF3 Q6UW59 |
| Accessions | EAW69239 EAW69240 Q96BF3 AY358964 AAQ89323 BC015655 AAH15655 BU629751 HQ452865 AED88282 HQ452866 AED88283 HY260382 XM_011527679 XP_011525981 NM_001169126 NP_001162597 NM_001308232 NP_001295161 NM_144615 NP_653216 |
| Function | Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:22419821}; Single-pass type I membrane protein {ECO:0000269|PubMed:22419821}. |
| Tissue Specificity | Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double- negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cel |
TMIGD2 CRISPR/Cas9 KO Plasmid (h) - sc-414261 from Santa Cruz Biotechnology
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TMIGD2 HDR Plasmid (h) - sc-414261-HDR from Santa Cruz Biotechnology
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TMIGD2 Double Nickase Plasmid (h) - sc-414261-NIC from Santa Cruz Biotechnology
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TMIGD2 Double Nickase Plasmid (h2) - sc-414261-NIC-2 from Santa Cruz Biotechnology
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TMIGD2 CRISPR Activation Plasmid (h) - sc-414261-ACT from Santa Cruz Biotechnology
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TMIGD2 CRISPR Activation Plasmid (h2) - sc-414261-ACT-2 from Santa Cruz Biotechnology
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TMIGD2 Lentiviral Activation Particles (h) - sc-414261-LAC from Santa Cruz Biotechnology
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TMIGD2 Lentiviral Activation Particles (h2) - sc-414261-LAC-2 from Santa Cruz Biotechnology
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TMIGD2 siRNA (h) - sc-97757 from Santa Cruz Biotechnology
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TMIGD2 shRNA Plasmid (h) - sc-97757-SH from Santa Cruz Biotechnology
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TMIGD2 shRNA (h) Lentiviral Particles - sc-97757-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU139191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21695 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21695 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03502 from Sigma-Aldrich
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TMIGD2 siRNA (Human) - CRJ4848 from Cohesion Biosciences
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TMIGD2 - MBS8221842 from MyBioSource
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shRNA set against Human TMIGD2 (NM_144615.2) - SHH431292 from Creative biogene
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Human TMIGD2 siRNA - orb275349 from Biorbyt
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TMIGD2 shRNA Plasmid (Human) - CHJ4848 from Cohesion Biosciences
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TMIGD2 miRNA 3'UTR clone - MiUTR4H-TG09196 from Creative biogene
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