FAM175A

Gene Symbol FAM175A
Entrez Gene 84142
Alt Symbol ABRA1, CCDC98
Species Human
Gene Type protein-coding
Description family with sequence similarity 175, member A
Other Description BRCA1-A complex subunit Abraxas|abraxas protein|coiled-coil domain containing 98|coiled-coil domain-containing protein 98
Swissprots A5JJ07 Q9H8I1 Q9H9N4 Q6UWZ7
Accessions EAX05941 EAX05942 EAX05943 Q6UWZ7 AK021582 AK022704 BAB14189 AK023676 BAB14635 AY358576 AAQ88939 BC016905 AAH16905 BC039573 AAH39573 BQ775930 DA765424 EF531340 ABP87396 XM_005263280 XP_005263337 XM_005263281 XP_005263338 XM_011532318 XP_011530620 NM_139076 NP_620775
Function Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538}.
Subcellular Location Nucleus {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).

CCDC98 (A-3) - sc-376951 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CCDC98 (A-3): sc-376951. Western blot analysis of CCDC98 expression in human testis tissue extract.

CCDC98 (F-17) - sc-104124 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CCDC98 (N-12) - sc-104125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CCDC98 (H-100) - sc-135220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-CCDC98 antibody - ab64272 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CCDC98 antibody (ab64272) at 1 µg/mlLane 1 : Pancreas (Mouse) Tissue LysateLane 2 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CCDC98 antibody - ab74343 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CCDC98 antibody (ab74343) at 1 µg/ml + Testis (Human) Tissue Lysate - adult normal tissue (ab30257) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CCDC98 antibody - ab113278 from Abcam

Prices $428.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human CCDC98 by Immunohistochemistry. Sample: FFPE section of Human ovarian carcinoma. ab113278 used at a dilution of 1/250. Detection: DAB staining.

Anti-CCDC98 antibody [ABRA1-01] - ab110097 from Abcam

Prices $407.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone ABRA1-01
ab110097 at 10µg/ml staining CCDC98 in Formalin/PFA-fixed paraffin-embedded Human tetis tissue.

Anti-CCDC98 antibody [ABRA1-01] - ab112070 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone ABRA1-01
Lane 1 : Anti-CCDC98 antibody [ABRA1-01] (ab112070) at 1 µg/mlLane 2 : anti-EGFP (polyclonal) at 1 µg/mlLane 1 : CCDC98-EGFP fusion transfected HEK293 cell lysateLane 2 : CCDC98-EGFP fusion transfected HEK293 cell lysate

Anti-CCDC98 antibody [EPR6310(2)] - ab139191 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6310(2)
Overlay histogram showing HeLa cells stained with ab139191 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab139191, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-CCDC98 antibody - C-terminal - ab195659 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CCDC98 antibody - C-terminal (ab195659) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µg

Anti-FAM175A / CCDC98 Antibody (C-Terminus) - LS-C151944 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FAM175A / CCDC98 antibody Western Blot of 293T cell lysate.

Anti-FAM175A / CCDC98 Antibody (aa350-400) IHC-plus™ - LS-B11158 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FAM175A / CCDC98 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11158 dilution 1:100.

Anti-FAM175A / CCDC98 Antibody (aa400-409) - LS-C286836 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Abraxas by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Abraxas used at a dilution of 1:250.

Anti-FAM175A / CCDC98 Antibody (aa400-409) - LS-C288934 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Abraxas by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Abraxas used at a dilution of 1:1000 (1 ug/ml).

Anti-FAM175A / CCDC98 Antibody (N-Terminus) - LS-C34740 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of CCDC98 in human breast tissue with CCDC98 antibody at 5 ug/ml.

Anti-FAM175A / CCDC98 Antibody (clone ABRA1-01) IHC-plus™ - LS-B4515 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone ABRA1-01
Anti-FAM175A / CCDC98 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4515 concentration 10 ug/ml.

Abraxas Antibody - NBP2-38356 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Abraxas Antibody [NBP2-38356] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG

Abraxas Antibody - NBP1-76827 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Abraxas Antibody [NBP1-76827] - Abraxas Antibody Human breast tissue lysate in (A) the absence and (B) presence of blocking peptide with CCDC98 antibody at 1 ug/ml.

Abraxas Antibody - NBP1-22978 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Abraxas Antibody (ABRA1-01) - NBP1-69762 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone ABRA1-01

Abraxas Antibody - NBP1-22977 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Abraxas Antibody [NBP1-22977] - Whole cell lysate from HeLa and 293T cells. Abraxas was also immunoprecipitated by rabbit anti-Abraxas antibody NBP1-22978.

Abraxas Antibody - NBP1-89298 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Abraxas Antibody [NBP1-89298] - Staining of human testis shows moderate nuclear positivity in seminiferous tubules.

Abraxas Antibody (ABRA1-01) [DyLight 350] - NBP1-69762UV from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone ABRA1-01

Abraxas Antibody (ABRA1-01) [DyLight 405] - NBP1-69762V from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone ABRA1-01
Search more