FAM175A

Gene Symbol FAM175A
Entrez Gene 84142
Alt Symbol ABRA1, CCDC98
Species Human
Gene Type protein-coding
Description family with sequence similarity 175, member A
Other Description BRCA1-A complex subunit Abraxas|abraxas protein|coiled-coil domain containing 98|coiled-coil domain-containing protein 98
Swissprots A5JJ07 Q9H8I1 Q9H9N4 Q6UWZ7
Accessions EAX05941 EAX05942 EAX05943 Q6UWZ7 AK021582 AK022704 BAB14189 AK023676 BAB14635 AY358576 AAQ88939 BC016905 AAH16905 BC039573 AAH39573 BQ775930 DA765424 EF531340 ABP87396 XM_005263280 XP_005263337 XM_005263281 XP_005263338 XM_011532318 XP_011530620 NM_139076 NP_620775
Function Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538}.
Subcellular Location Nucleus {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).

CCDC98 CRISPR/Cas9 KO Plasmid (h) - sc-406939 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC98 HDR Plasmid (h) - sc-406939-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC98 Double Nickase Plasmid (h) - sc-406939-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC98 Double Nickase Plasmid (h2) - sc-406939-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC98 CRISPR Activation Plasmid (h) - sc-406939-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC98 CRISPR Activation Plasmid (h2) - sc-406939-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC98 Lentiviral Activation Particles (h) - sc-406939-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC98 Lentiviral Activation Particles (h2) - sc-406939-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC98 siRNA (h) - sc-105186 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCDC98 shRNA Plasmid (h) - sc-105186-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCDC98 shRNA (h) Lentiviral Particles - sc-105186-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU129371 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN8239 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8239 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FAM175A siRNA (Human) - CRJ3320 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FAM175A - MBS8210353 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FAM175A (NM_139076.2) - SHH290221 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CCDC98(NM_139076.2) - SHG134225 from Creative biogene

Category siRNA
Species Reactivities Human

FAM175A shRNA Plasmid (Human) - CHJ3320 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FAM175A miRNA 3'UTR clone - MiUTR1H-01785 from Creative biogene

Species Reactivities Human
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