FAM175A

Gene Symbol	FAM175A
Entrez Gene	84142
Alt Symbol	ABRA1, CCDC98
Species	Human
Gene Type	protein-coding
Description	family with sequence similarity 175, member A
Other Description	BRCA1-A complex subunit Abraxas|abraxas protein|coiled-coil domain containing 98|coiled-coil domain-containing protein 98
Swissprots	A5JJ07 Q9H8I1 Q9H9N4 Q6UWZ7
Accessions	EAX05941 EAX05942 EAX05943 Q6UWZ7 AK021582 AK022704 BAB14189 AK023676 BAB14635 AY358576 AAQ88939 BC016905 AAH16905 BC039573 AAH39573 BQ775930 DA765424 EF531340 ABP87396 XM_005263280 XP_005263337 XM_005263281 XP_005263338 XM_011532318 XP_011530620 NM_139076 NP_620775
Function	Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CCDC98 peptide - ab74341 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CCDC98 peptide - ab74342 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

FAM175A / CCDC98 Antibody Blocking Peptide - LS-E30386 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FAM175A / CCDC98 Antibody Blocking Peptide - LS-E23778 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Abraxas Blocking Peptide - NBP1-76827PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

FAM175A-Antibody-Center-Blocking-Peptide - BP9636c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CCDC98 Peptide - GTX85433-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

CCDC98 Control Peptide - AP30214CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CCDC98 Peptide - 4321P from ProSci Category Peptide Species Human

FAM175A fusion protein - ag5688 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

FAM175A fusion protein - Ag6897 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human BRCA1-A complex subunit Abraxas(FAM175A) - CSB-YP747632HU CSB-EP747632HU CSB-BP747632HU CSB-MP747632HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Salmo salar BRCA1-A complex subunit Abraxas(fam175a) - CSB-YP008138SWI CSB-EP008138SWI CSB-BP008138SWI CSB-MP008138SWI from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

Abraxas Protein - NBP2-38356PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Abraxas Protein - NBP1-89298PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

FAM175A Peptide, Human - M34GP05319H from Creative Peptides Category Peptide Source Synthetic. Species Human

FAM175A Antibody - SH-A12022 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

BRCA1-A complex subunit Abraxas (FAM175A), Recombinant Protein - MBS1430284 from MyBioSource Category Protein Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,900.00, $1,900.00, $2,365.00, $2,365.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

BRCA1-A complex subunit Abraxas (fam175a), Recombinant Protein - MBS1119866 from MyBioSource Category Protein Prices $1,175.00, $1,175.00, $1,395.00, $1,395.00, $1,890.00, $1,890.00, $2,355.00, $2,355.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

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