| Gene Symbol |
TRIP6
|
| Entrez Gene |
7205
|
| Alt Symbol |
OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thyroid hormone receptor interactor 6
|
| Other Description |
OPA-interacting protein 1|TR-interacting protein 6|thyroid hormone receptor interacting protein 6|thyroid receptor-interacting protein 6|zyxin related protein 1
|
| Swissprots |
F2ZC08 O15275 Q9BUE5 A4D2E7 Q9UNT4 Q9BTB2 Q15654 F2ZC07 O15170 Q9BXP3
|
| Accessions |
AAD03037 AAK21007 EAL23817 EAW76471 EAW76472 EAW76473 EAW76474 Q15654 AB628085 BAK20496 AB628086 BAK20497 AB628087 BAK20498 AB628088 BAK20499 AF000974 AAB62222 AF025437 AAC39557 AJ001902 CAA05080 AK056773 AK291906 BAF84595 AK309312 BC002680 AAH02680 BC004249 AAH04249 BC004999 AAH04999 BC021540 AAH21540 BC028985 AAH28985 BM800083 CR749505 CAH18326 DQ892893 ABM83819 DQ896140 ABM87139 L40374 AAC41740 XM_011516545 XP_011514847 NM_003302 NP_003293
|
| Function |
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16624523}. Cell junction, focal adhesion {ECO:0000269|PubMed:16624523}. Nucleus {ECO:0000269|PubMed:16624523}. Cytoplasm {ECO:0000269|PubMed:16624523}. Note=Shuttles between nucleus and cytoplasm.
|
| Tissue Specificity |
Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors. {ECO:0000269|PubMed:19017743}.
|
| Top Pathways |
NOD-like receptor signaling pathway
|
![Western Blot: TRIP6 Overexpression Lysate (Adult Normal) [NBL1-17321] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TRIP6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4662_TRIP6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17321-img0002.jpg)