DNAJA3

Gene Symbol DNAJA3
Entrez Gene 9093
Alt Symbol HCA57, TID1, hTID-1
Species Human
Gene Type protein-coding
Description DnaJ (Hsp40) homolog, subfamily A, member 3
Other Description dnaJ homolog subfamily A member 3, mitochondrial|dnaJ protein Tid-1|hepatocellular carcinoma-associated antigen 57|tumorous imaginal discs protein Tid56 homolog
Swissprots Q96D76 Q9NYH8 Q96EY1 Q8WUJ6 Q96IV1 Q8WXJ3 B2RAJ5 B4DI33 E7ES32 O75472
Accessions EAW85303 EAW85304 EAW85305 Q96EY1 AB209923 BAD93160 AF061749 AAC29066 AF244136 AAF66245 AF411044 AAL35323 AK001333 BAG50893 AK127660 AK223105 BAD96825 AK295391 BAG58345 AK314218 BAG36892 BC007225 AAH07225 BC011855 AAH11855 BC012343 AAH12343 BC014062 AAH14062 BC020248 AAH20248 BC030145 AAH30145 BC032100 AAH32100 BX445320 DA172592 NM_001135110 NP_001128582 NM_001286516 NP_001273445 NM_005147 NP_005138
Function Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Subcellular Location Mitochondrion matrix. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. {ECO:0000269|PubMed:9683573}.
Top Pathways Viral carcinogenesis

Tid-1 (RS13) Mouse mAb - 4775 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone RS13
Western blot analysis of extracts from Jurkat (human), C6 (rat), and L929 (mouse) cells, using Tid-1 (RS13) Mouse mAb.

TID-1 L (C-15) - sc-5873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TID-1<sub>L</sub> (C-15): sc-5873. Western blot analysis of TID-1<sub>L</sub> expression in HeLa (A), Jurkat (B) and K-562 (C) whole cell lysates.

TID-1 L/S (E-16) - sc-5869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TID-1<sub>L/S</sub> (E-16): sc-5869. Western blot analysis of TID-1<sub>L/S</sub> expression in HeLa (A), Jurkat (B), MES-SA/Dx5 (C) and HL-60 (D) whole cell lysates.

TID-1 L/S (H-300) - sc-367497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TID-1 L/S (RS-11) - sc-18820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TID-1<sub>L/S</sub> (RS11): sc-18820. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

TID-1 L/S (RS-13) - sc-18819 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TID-1L/S (RS13): sc-18819. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

TID-1 L/S (SPM454) - sc-56488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

TID-1 S (S-9) - sc-5874 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TID-1<sub>S</sub> (S-9): sc-5874. Western blot analysis of TID-1<sub>S</sub> expression in HeLa (A) and Jurkat (B) whole cell lysates.

Anti-TID1 antibody - ab115697 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry Image of Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with TID1 antibody (ab115697) at 10 &microg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TID1 antibody - ab125701 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab125701, at 1/500 dilution, staining TID1 (Green) in Methanol-fixed HeLa cells by Immunocytochemistry/Immunofluorescence.

Anti-TID1 antibody - ab55814 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TID1 antibody [EPR12414] - ab181024 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12414
All lanes : Anti-TID1 antibody [EPR12414] (ab181024) at 1/5000 dilutionLane 1 : JAR cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLane 4 : K562 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TID1 antibody [RS13] - ab81700 from Abcam

Prices $406.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone RS13
anti TID1 (a different form of ab81700 containing BSA and azide) at 2 µg/ml + human cells

Anti-DNAJA3 / TID1 Antibody (aa105-134, Azide-free, HRP) - LS-C213605 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJA3 / TID1 Antibody (aa105-134, PE) - LS-C213606 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJA3 / TID1 Antibody (aa105-134, Biotin) - LS-C213603 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJA3 / TID1 Antibody - LS-C307273 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DNAJA3 / TID1 Antibody (aa104-134) - LS-C320883 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJA3 / TID1 Antibody (aa105-134) - LS-C167462 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DNAJA3 Antibody western blot of HeLa cell line lysates (35 ug/lane). The DNAJA3 antibody detected the DNAJA3 protein (arrow).

Anti-DNAJA3 / TID1 Antibody - LS-C346191 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of U20S cell using DNAJA3 antibody. Blue: DAPI for nuclear staining.

Anti-DNAJA3 / TID1 Antibody (C-Terminus) IHC-plus™ - LS-B2634 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DNAJA3 / TID1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2634 concentration 10 ug/ml.

Anti-DNAJA3 / TID1 Antibody - LS-C155175 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded BT483 xenograft, using TID1 antibody at 1:250 dilution.

Anti-DNAJA3 / TID1 Antibody - LS-C18104 from LifeSpan Bioscience

Prices $455.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-DNAJA3 / TID1 Antibody - LS-C18105 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-DNAJA3 / TID1 Antibody (clone RS13, Azide-free) - LS-C87805 from LifeSpan Bioscience

Prices $620.00, $1,015.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone RS13
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