DNAJA3

Gene Symbol	DNAJA3
Entrez Gene	9093
Alt Symbol	HCA57, TID1, hTID-1
Species	Human
Gene Type	protein-coding
Description	DnaJ (Hsp40) homolog, subfamily A, member 3
Other Description	dnaJ homolog subfamily A member 3, mitochondrial|dnaJ protein Tid-1|hepatocellular carcinoma-associated antigen 57|tumorous imaginal discs protein Tid56 homolog
Swissprots	Q96D76 Q9NYH8 Q96EY1 Q8WUJ6 Q96IV1 Q8WXJ3 B2RAJ5 B4DI33 E7ES32 O75472
Accessions	EAW85303 EAW85304 EAW85305 Q96EY1 AB209923 BAD93160 AF061749 AAC29066 AF244136 AAF66245 AF411044 AAL35323 AK001333 BAG50893 AK127660 AK223105 BAD96825 AK295391 BAG58345 AK314218 BAG36892 BC007225 AAH07225 BC011855 AAH11855 BC012343 AAH12343 BC014062 AAH14062 BC020248 AAH20248 BC030145 AAH30145 BC032100 AAH32100 BX445320 DA172592 NM_001135110 NP_001128582 NM_001286516 NP_001273445 NM_005147 NP_005138
Function	Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Subcellular Location	Mitochondrion matrix. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. {ECO:0000250}.
Tissue Specificity	Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. {ECO:0000269|PubMed:9683573}.
Top Pathways	Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TID1 full length protein - ab160336 from Abcam Category Protein Source Wheat germ Species Human

Human TID1 protein fragment - ab160337 from Abcam Category Protein Source Wheat germ Species Human

DNAJA3 / TID1 Antibody Blocking Peptide - LS-E3553 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNAJA3 / TID1 Antibody Blocking Peptide - LS-E23494 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TID1 Protein - H00009093-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TID1 Protein - H00009093-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

DNAJA3-Antibody-N-term-Blocking-Peptide - BP14750a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TID1-Antibody-N-term-Blocking-Peptide - BP16189a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DNAJA3 / TID1 - H00009093-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

DNAJA3 / TID1 - H00009093-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DNAJA3 / TID1 - H00009093-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DNAJA3 fusion protein - ag1558 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DnaJ homolog subfamily A member 3, mitochondrial(DNAJA3) ,partial - CSB-YP836207HU CSB-EP836207HU CSB-BP836207HU CSB-MP836207HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DNAJA3 / TID1 (transcript variant 1) - TP304240 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TID1 Recombinant Protein Antigen - NBP2-34066PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TID1 Recombinant Protein Antigen - NBP2-33416PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNAJA3 Peptide, Human - M34GP04400H from Creative Peptides Category Peptide Source Synthetic. Species Human

DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3), partial, Recombinant Protein - MBS1324046 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

DNAJA3 fusion protein - Ag26556 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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