DNAJA3

Gene Symbol DNAJA3
Entrez Gene 9093
Alt Symbol HCA57, TID1, hTID-1
Species Human
Gene Type protein-coding
Description DnaJ (Hsp40) homolog, subfamily A, member 3
Other Description dnaJ homolog subfamily A member 3, mitochondrial|dnaJ protein Tid-1|hepatocellular carcinoma-associated antigen 57|tumorous imaginal discs protein Tid56 homolog
Swissprots Q96D76 Q9NYH8 Q96EY1 Q8WUJ6 Q96IV1 Q8WXJ3 B2RAJ5 B4DI33 E7ES32 O75472
Accessions EAW85303 EAW85304 EAW85305 Q96EY1 AB209923 BAD93160 AF061749 AAC29066 AF244136 AAF66245 AF411044 AAL35323 AK001333 BAG50893 AK127660 AK223105 BAD96825 AK295391 BAG58345 AK314218 BAG36892 BC007225 AAH07225 BC011855 AAH11855 BC012343 AAH12343 BC014062 AAH14062 BC020248 AAH20248 BC030145 AAH30145 BC032100 AAH32100 BX445320 DA172592 NM_001135110 NP_001128582 NM_001286516 NP_001273445 NM_005147 NP_005138
Function Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Subcellular Location Mitochondrion matrix. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. {ECO:0000269|PubMed:9683573}.
Top Pathways Viral carcinogenesis

DNAJA3-Over-expression-Lysate - LY14761a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag DNAJA3 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 89) or transiently transfected with theDNAJA3 gene.

DNAJA3 293 Cell Lysate - 408182 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

TID1 Overexpression Lysate (Denatured) - H00009093-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: DNAJA3 transfected lysate (52.5 KDa) Lane 2: Non-transfected lysate.

DNAJA3 Over-expression Lysate Product - GWB-63FB37 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

TID1 Overexpression Lysate (Native) - NBP2-10517 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

Panoply™ Human DNAJA3 Knockdown Stable Cell Line - CSC-DC004400 from Creative biogene

Category Cell Line
Species Human
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