DNAJA3
| Gene Symbol | DNAJA3 |
|---|---|
| Entrez Gene | 9093 |
| Alt Symbol | HCA57, TID1, hTID-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | DnaJ (Hsp40) homolog, subfamily A, member 3 |
| Other Description | dnaJ homolog subfamily A member 3, mitochondrial|dnaJ protein Tid-1|hepatocellular carcinoma-associated antigen 57|tumorous imaginal discs protein Tid56 homolog |
| Swissprots | Q96D76 Q9NYH8 Q96EY1 Q8WUJ6 Q96IV1 Q8WXJ3 B2RAJ5 B4DI33 E7ES32 O75472 |
| Accessions | EAW85303 EAW85304 EAW85305 Q96EY1 AB209923 BAD93160 AF061749 AAC29066 AF244136 AAF66245 AF411044 AAL35323 AK001333 BAG50893 AK127660 AK223105 BAD96825 AK295391 BAG58345 AK314218 BAG36892 BC007225 AAH07225 BC011855 AAH11855 BC012343 AAH12343 BC014062 AAH14062 BC020248 AAH20248 BC030145 AAH30145 BC032100 AAH32100 BX445320 DA172592 NM_001135110 NP_001128582 NM_001286516 NP_001273445 NM_005147 NP_005138 |
| Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Subcellular Location | Mitochondrion matrix. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. {ECO:0000250}. |
| Tissue Specificity | Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. {ECO:0000269|PubMed:9683573}. |
| Top Pathways | Viral carcinogenesis |
TID-1 L/S CRISPR/Cas9 KO Plasmid (h) - sc-404796 from Santa Cruz Biotechnology
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TID-1 L/S HDR Plasmid (h) - sc-404796-HDR from Santa Cruz Biotechnology
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TID-1 L/S Double Nickase Plasmid (h) - sc-404796-NIC from Santa Cruz Biotechnology
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TID-1 L/S Double Nickase Plasmid (h2) - sc-404796-NIC-2 from Santa Cruz Biotechnology
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TID-1 L/S CRISPR Activation Plasmid (h) - sc-404796-ACT from Santa Cruz Biotechnology
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TID-1 L/S CRISPR Activation Plasmid (h2) - sc-404796-ACT-2 from Santa Cruz Biotechnology
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TID-1 L/S Lentiviral Activation Particles (h) - sc-404796-LAC from Santa Cruz Biotechnology
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TID-1 L/S Lentiviral Activation Particles (h2) - sc-404796-LAC-2 from Santa Cruz Biotechnology
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TID-1 L/S siRNA (h) - sc-36673 from Santa Cruz Biotechnology
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TID-1 L/S shRNA Plasmid (h) - sc-36673-SH from Santa Cruz Biotechnology
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TID-1 L/S shRNA (h) Lentiviral Particles - sc-36673-V from Santa Cruz Biotechnology
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TID1 RNAi - H00009093-R01 from Novus Biologicals
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MISSION® esiRNA - EHU091601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7342 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7342 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08494 from Sigma-Aldrich
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DNAJA3 siRNA (Human) - CRH6006 from Cohesion Biosciences
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DNAJA3 - MBS8210462 from MyBioSource
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shRNA set against Human DNAJA3 (NM_005147.5) - SHH279237 from Creative biogene
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Human DNAJA3 siRNA - orb266508 from Biorbyt
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DNAJA3 shRNA Plasmid (Human) - CHH6006 from Cohesion Biosciences
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DNAJA3 miRNA 3'UTR clone - MiUTR3H-09964 from Creative biogene
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DNAJA3 miRNA 3'UTR clone - MiUTR3H-09965 from Creative biogene
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