| Gene Symbol |
STXBP5
|
| Entrez Gene |
134957
|
| Alt Symbol |
LGL3, LLGL3, Nbla04300
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
syntaxin binding protein 5 (tomosyn)
|
| Other Description |
lethal(2) giant larvae protein homolog 3|putative protein product of Nbla04300|syntaxin-binding protein 5|tomosyn|tomosyn-1
|
| Swissprots |
Q5T5C1 Q14DF3 Q5T5C0 Q96NG9 Q8NBG8 Q5T5C2
|
| Accessions |
EAW47819 EAW47820 EAW47821 EAW47822 EAW47823 Q5T5C0 AB073398 BAE45727 AI079651 AK055484 BAB70930 AK090549 BAC03475 AK128121 BAG54632 AL834152 AW020148 BC043173 BC043645 BC065713 BC107737 AAI07738 BC113382 AAI13383 BC113408 AAI13409 CB140025 HG499775 XM_006715339 XP_006715402 XM_011535449 XP_011533751 XM_011535450 XP_011533752 XM_011535451 XP_011533753 XM_011535452 XP_011533754 XM_011535453 XP_011533755 XM_011535454 XP_011533756 XR_245502 XR_245504 XR_942280 XR_942282 XR_942284 XR_942285 NM_001127715 NP_001121187 NM_139244 NP_640337
|
| Function |
Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity). {ECO:0000250}.
|
![Western Blot: Tomosyn Overexpression Lysate (Adult Normal) [NBP2-11139] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Tomosyn.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2364_Tomosyn%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11139-img0001.jpg)