Gene Symbol | STXBP5 |
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Entrez Gene | 134957 |
Alt Symbol | LGL3, LLGL3, Nbla04300 |
Species | Human |
Gene Type | protein-coding |
Description | syntaxin binding protein 5 (tomosyn) |
Other Description | lethal(2) giant larvae protein homolog 3|putative protein product of Nbla04300|syntaxin-binding protein 5|tomosyn|tomosyn-1 |
Swissprots | Q5T5C1 Q14DF3 Q5T5C0 Q96NG9 Q8NBG8 Q5T5C2 |
Accessions | EAW47819 EAW47820 EAW47821 EAW47822 EAW47823 Q5T5C0 AB073398 BAE45727 AI079651 AK055484 BAB70930 AK090549 BAC03475 AK128121 BAG54632 AL834152 AW020148 BC043173 BC043645 BC065713 BC107737 AAI07738 BC113382 AAI13383 BC113408 AAI13409 CB140025 HG499775 XM_006715339 XP_006715402 XM_011535449 XP_011533751 XM_011535450 XP_011533752 XM_011535451 XP_011533753 XM_011535452 XP_011533754 XM_011535453 XP_011533755 XM_011535454 XP_011533756 XR_245502 XR_245504 XR_942280 XR_942282 XR_942284 XR_942285 NM_001127715 NP_001121187 NM_139244 NP_640337 |
Function | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity). {ECO:0000250}. |
Tomosyn CRISPR/Cas9 KO Plasmid (h) - sc-403625 from Santa Cruz Biotechnology
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Tomosyn HDR Plasmid (h) - sc-403625-HDR from Santa Cruz Biotechnology
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Tomosyn Double Nickase Plasmid (h) - sc-403625-NIC from Santa Cruz Biotechnology
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Tomosyn Double Nickase Plasmid (h2) - sc-403625-NIC-2 from Santa Cruz Biotechnology
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Tomosyn CRISPR Activation Plasmid (h) - sc-403625-ACT from Santa Cruz Biotechnology
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Tomosyn CRISPR Activation Plasmid (h2) - sc-403625-ACT-2 from Santa Cruz Biotechnology
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Tomosyn Lentiviral Activation Particles (h) - sc-403625-LAC from Santa Cruz Biotechnology
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Tomosyn Lentiviral Activation Particles (h2) - sc-403625-LAC-2 from Santa Cruz Biotechnology
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Tomosyn siRNA (h) - sc-76713 from Santa Cruz Biotechnology
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Tomosyn shRNA Plasmid (h) - sc-76713-SH from Santa Cruz Biotechnology
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Tomosyn shRNA (h) Lentiviral Particles - sc-76713-V from Santa Cruz Biotechnology
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Tomosyn RNAi - H00134957-R01 from Novus Biologicals
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MISSION® esiRNA - EHU000011 from Sigma-Aldrich
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MISSION® esiRNA - EHU067801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20795 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07621 from Sigma-Aldrich
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STXBP5 siRNA (Human) - CRJ5157 from Cohesion Biosciences
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STXBP5 - MBS8219626 from MyBioSource
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shRNA set against Human STXBP5 (NM_139244.4) - SHH420484 from Creative biogene
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Human STXBP5 siRNA - orb275658 from Biorbyt
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STXBP5 shRNA Plasmid (Human) - CHJ5157 from Cohesion Biosciences
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