ACER2

Gene Symbol ACER2
Entrez Gene 340485
Alt Symbol ALKCDase2, ASAH3L
Species Human
Gene Type protein-coding
Description alkaline ceramidase 2
Other Description alkCDase 2|alkaline CDase 2|ceramide hydrolase|haCER2
Swissprots A2A3R8 Q5VZR7 Q569G5 Q5QJU3 Q71RD2
Accessions EAW58634 Q5QJU3 AF370405 AAQ15241 AK123581 BAG53917 AY312516 AAQ85132 BC092487 AAH92487 XM_005251447 XP_005251504 XM_005251448 XP_005251505 XM_011517856 XP_011516158 XM_011517857 XP_011516159 XM_011517858 XP_011516160 XM_011517859 XP_011516161 XR_242505 XR_242506 XR_242507 XR_929240 XR_929241 NM_001010887 NP_001010887
Function Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. {ECO:0000269|PubMed:16940153, E
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856}; Multi- pass membrane protein {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856}.
Tissue Specificity Highly expressed in placenta. {ECO:0000269|PubMed:16940153}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

Anti-ASAH3L antibody - ab101556 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed and paraffin embedded Human fetal liver tissue labelled with ab101556 at 1/100 dilution.

Anti-ASAH3L antibody - ab134235 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ASAH3L antibody (ab134235) at 1 µg/ml + Human fetal lung lysate at 10 µg

Anti-ACER2 Antibody (aa93-142) - LS-C152143 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ACER2 antibody Western Blot of Fetal Lung.

Alkaline Ceramidase 2 Antibody - NBP1-90089 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Alkaline Ceramidase 2 Antibody [NBP1-90089] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Anti-ACER2 antibody produced in rabbit - HPA014092 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ASAH3L: <B>Cat. No. HPA014092</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver shows strong cytoplasmic positivity in hepatocytes.

ACER2 Antibody - middle region (ARP66122_P050) - ARP66122_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ASAH3L-Antibody - AP50775 from Abgent, a WuXi AppTec company

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from human placenta tissue lysate,using ASAH3L Antibody(AP50775). AP50775 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.

ACER2 Antibody (OAAB18568) - OAAB18568 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ACER2 Antibody (OAAF03260) - OAAF03260 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ACER2 antibody - orb77488 from Biorbyt

Prices $425.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin embedded fetal liver showing cytoplasmic staining using ACER2 antibody

ASAH3L antibody - orb226285 from Biorbyt

Prices $196.00, $238.00, $323.00
Sizes 20 μl, 50 μl, 100 μl
Host Rabbit
Clonality Polyclonal

ACER2 Antibody - abx121249 from Abbexa

Host Rabbit
Clonality Polyclonal

ACER2 Antibody - abx037738 from Abbexa

Prices $343.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

ASAH3L Antibody - abx014172 from Abbexa

Host Rabbit
Clonality Polyclonal

ASAH3L Antibody - 34404 from Signalway Antibody

Prices $189.00, $279.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS7 cells, using ASAH3L antibody #34404.

ACER2 Antibody - E301570 from Enogene

Prices $275.00
Sizes 100ug/200ul

ASAH3L Antibody - E11-14402C from Enogene

Prices $225.00
Sizes 100 μg
Host Rabbit

ACER2, Polyclonal Antibody - MBS859869 from MyBioSource

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACER2 (aa 93-142) polyclonal antibody - DPABH-25574 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-ACER2 Antibody - CPA3748 from Cohesion Biosciences

Prices $110.00, $220.00, $350.00
Sizes 30 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of ACER2 expression in A549.MCF7 (A); PC12 (B) whole cell lysates.

ACER2 polyclonal antibody - BS60828 from Bioworld Technology

Prices $158.00, $275.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot (WB) analysis of ACER2 pAb at 1:500 dilution Lane1:A549 whole cell lysate Lane2:MCF-7 whole cell lysate Lane3:PC12 whole cell lysate

ACER2 Antibody - CSB-PA293630 from Cusabio

Host Rabbit
Clonality Polyclonal

ASAH3L Antibody - A02A0292 from BlueGene Biotech

Anti-ACER2 Antibody (Internal) - LS-C354506 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of ACER2 expression in A549.MCF7 (A); PC12 (B) whole cell lysates.

ACER2 antibody - GTX54882 from GeneTex

Prices $319.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Anti-ACER2 antibody used in Western blot. GTX54882
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