| Gene Symbol |
ACER2
|
| Entrez Gene |
340485
|
| Alt Symbol |
ALKCDase2, ASAH3L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alkaline ceramidase 2
|
| Other Description |
alkCDase 2|alkaline CDase 2|ceramide hydrolase|haCER2
|
| Swissprots |
A2A3R8 Q5VZR7 Q569G5 Q5QJU3 Q71RD2
|
| Accessions |
EAW58634 Q5QJU3 AF370405 AAQ15241 AK123581 BAG53917 AY312516 AAQ85132 BC092487 AAH92487 XM_005251447 XP_005251504 XM_005251448 XP_005251505 XM_011517856 XP_011516158 XM_011517857 XP_011516159 XM_011517858 XP_011516160 XM_011517859 XP_011516161 XR_242505 XR_242506 XR_242507 XR_929240 XR_929241 NM_001010887 NP_001010887
|
| Function |
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. {ECO:0000269|PubMed:16940153, E
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856}; Multi- pass membrane protein {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856}.
|
| Tissue Specificity |
Highly expressed in placenta. {ECO:0000269|PubMed:16940153}.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|