| Gene Symbol |
TRIM40
|
| Entrez Gene |
135644
|
| Alt Symbol |
RNF35
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 40
|
| Other Description |
RING finger protein 35|probable E3 NEDD8-protein ligase|ring finger RNF35|tripartite motif-containing protein 40
|
| Swissprots |
Q8TD96 Q5SS36 Q5SRJ6 Q6P9F5
|
| Accessions |
BAD13705 BAD13706 BAE78604 EAX03265 EAX03266 Q6P9F5 AF489517 AAM09503 BC060785 AAH60785 CB990357 EU446570 ABZ92099 XM_011514305 XP_011512607 XM_011514306 XP_011512608 XM_011514307 XP_011512609 XM_011514308 XP_011512610 XM_011514309 XP_011512611 XM_011547189 XP_011545491 XM_011547190 XP_011545492 XM_011547191 XP_011545493 XM_011547192 XP_011545494 XM_011547604 XP_011545906 XM_011547842 XP_011546144 XM_011547843 XP_011546145 XM_011548011 XP_011546313 XM_011548012 XP_011546314 XM_011548013 XP_011546315 XM_011548199 XP_011546501 XM_011548200 XP_011546502 XM_011548201 XP_011546503 XM_011548202 XP_011546504 XM_011548384 XP_011546686 XM_011548385 XP_011546687 XM_011548386 XP_011546688 NM_001286633 NP_001273562 NM_138700 NP_619645
|
| Function |
May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity. {ECO:0000269|PubMed:21474709}.
|
| Tissue Specificity |
Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract. {ECO:0000269|PubMed:21474709}.
|
![Western Blot: TRIM40 Overexpression Lysate (Adult Normal) [NBP2-05640] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TRIM40.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10547_TRIM40%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05640-img0001.jpg)