Gene Symbol | TRIM40 |
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Entrez Gene | 135644 |
Alt Symbol | RNF35 |
Species | Human |
Gene Type | protein-coding |
Description | tripartite motif containing 40 |
Other Description | RING finger protein 35|probable E3 NEDD8-protein ligase|ring finger RNF35|tripartite motif-containing protein 40 |
Swissprots | Q8TD96 Q5SS36 Q5SRJ6 Q6P9F5 |
Accessions | BAD13705 BAD13706 BAE78604 EAX03265 EAX03266 Q6P9F5 AF489517 AAM09503 BC060785 AAH60785 CB990357 EU446570 ABZ92099 XM_011514305 XP_011512607 XM_011514306 XP_011512608 XM_011514307 XP_011512609 XM_011514308 XP_011512610 XM_011514309 XP_011512611 XM_011547189 XP_011545491 XM_011547190 XP_011545492 XM_011547191 XP_011545493 XM_011547192 XP_011545494 XM_011547604 XP_011545906 XM_011547842 XP_011546144 XM_011547843 XP_011546145 XM_011548011 XP_011546313 XM_011548012 XP_011546314 XM_011548013 XP_011546315 XM_011548199 XP_011546501 XM_011548200 XP_011546502 XM_011548201 XP_011546503 XM_011548202 XP_011546504 XM_011548384 XP_011546686 XM_011548385 XP_011546687 XM_011548386 XP_011546688 NM_001286633 NP_001273562 NM_138700 NP_619645 |
Function | May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity. {ECO:0000269|PubMed:21474709}. |
Tissue Specificity | Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract. {ECO:0000269|PubMed:21474709}. |
TRIM40 CRISPR/Cas9 KO Plasmid (h) - sc-418544 from Santa Cruz Biotechnology
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TRIM40 HDR Plasmid (h) - sc-418544-HDR from Santa Cruz Biotechnology
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TRIM40 Double Nickase Plasmid (h) - sc-418544-NIC from Santa Cruz Biotechnology
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TRIM40 Double Nickase Plasmid (h2) - sc-418544-NIC-2 from Santa Cruz Biotechnology
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TRIM40 CRISPR Activation Plasmid (h) - sc-418544-ACT from Santa Cruz Biotechnology
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TRIM40 CRISPR Activation Plasmid (h2) - sc-418544-ACT-2 from Santa Cruz Biotechnology
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TRIM40 Lentiviral Activation Particles (h) - sc-418544-LAC from Santa Cruz Biotechnology
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TRIM40 Lentiviral Activation Particles (h2) - sc-418544-LAC-2 from Santa Cruz Biotechnology
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TRIM40 siRNA (h) - sc-95641 from Santa Cruz Biotechnology
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TRIM40 shRNA Plasmid (h) - sc-95641-SH from Santa Cruz Biotechnology
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TRIM40 shRNA (h) Lentiviral Particles - sc-95641-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU127611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21980 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21980 from Sigma-Aldrich
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TRIM40 siRNA (Human) - CRJ5169 from Cohesion Biosciences
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TRIM40 RNAi - H00135644-R01 from Novus Biologicals
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TRIM40 - MBS8203851 from MyBioSource
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shRNA set against Human TRIM40 (NM_138700.3) - SHH434720 from Creative biogene
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shRNA set against Human TRIM40(NM_138700.3) - SHL094746 from Creative biogene
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TRIM40 shRNA Plasmid (Human) - CHJ5169 from Cohesion Biosciences
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