MLX

Gene Symbol MLX
Entrez Gene 6945
Alt Symbol MAD7, MXD7, TCFL4, bHLHd13
Species Human
Gene Type protein-coding
Description MLX, MAX dimerization protein
Other Description BigMax protein|MAX-like bHLHZIP protein|class D basic helix-loop-helix protein 13|max-like protein X|transcription factor-like protein 4
Swissprots Q9H2V1 Q53XM6 Q9H2V2 B2RD73 B2RAV8 Q9H2V0 Q96FL2 Q9NXN3 Q9UH92 A8K2J3
Accessions EAW60841 EAW60842 EAW60843 EAW60844 EAW60845 Q9UH92 AA024982 AB209235 BAD92472 AF203978 AAF14638 AF213666 AAG40145 AF213667 AAG40146 AF213668 AAG40147 AK000150 BAA90977 AK290258 BAF82947 AK296114 BAG58863 AK303221 BAG64308 AK309628 AK314378 BAG37005 AK315432 BAG37820 BC010689 AAH10689 BC014537 BE907687 BI517590 BQ186038 BT009812 AAP88814 NM_170607 NP_733752 NM_198204 NP_937847 NM_198205 NP_937848
Function Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Subcellular Location Isoform Gamma: Nucleus. Note=Found predominantly in the nucleus.
Tissue Specificity Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung. {ECO:0000269|PubMed:10593926}.
Top Pathways Non-alcoholic fatty liver disease (NAFLD)

Mlx (F-12) - sc-393086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mlx (F-12): sc-393086. Western blot analysis of Mlx expression in non-transfected: sc-110760 (A) and human Mlx transfected: sc-111152 (B) 293 whole cell lysates.

Mlx (N-17) - sc-14705 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mlx (N-17): sc-14705. Western blot analysis of Mlx expression in non-transfected: sc-110760 (A) and human Mlx transfected: sc-111152 (B) 293 whole cell lysates.

Anti-MLX antibody - ab130384 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab130384, at 3.8 µg, staining MLX in paraffin-embedded Human placenta tissue by Immunohistochemistry, with Alkaline Phosphatase staining.

Anti-MLX antibody - ab65147 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MLX antibody (ab65147) at 1/500 dilutionLane 1 : LOVO cell extractLane 2 : LOVO cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-MLX antibody - ab167286 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MLX antibody (ab167286) at 1 µg/mlLane 1 : Transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-mouse HRP at 1/2500 dilution

Anti-MLX / TCFL4 Antibody (aa72-121) - LS-C109790 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MLX antibody LS-C109790 Western blot of Transfected 293T cell lysate.

Anti-MLX / TCFL4 Antibody (Internal, APC) - LS-C206742 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody (Gln136) - LS-C176839 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Mlx (Q136) pAb in extracts from LOVO cells.

Anti-MLX / TCFL4 Antibody (aa111-160) - LS-C119307 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from LOVO cells, using Mlx Antibody. The lane on the right is treated with the synthesized peptide.

Anti-MLX / TCFL4 Antibody (Internal, Biotin) - LS-C206743 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody (aa201-250) - LS-C80294 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MLX antibody LS-C80294 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-MLX / TCFL4 Antibody (Internal, FITC) - LS-C206744 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody (Internal, PE) - LS-C206745 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody (Internal, Azide-free, HRP) - LS-C209113 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody (Internal, Azide-free) - LS-C327926 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody - LS-C309020 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody (clone 1C3) - LS-C198316 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C3
Immunofluorescence of monoclonal antibody to MLX on HeLa cell . [antibody concentration 10 ug/ml]

Anti-MLX / TCFL4 Antibody (aa217-231) IHC-plus™ - LS-B6494 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MLX antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6494 concentration 2.5 ug/ml.

Anti-MLX / TCFL4 Antibody (aa125-151) - LS-C164223 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma with MLX Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-MLX / TCFL4 Antibody (aa197-298) - LS-C72745 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody (aa201-250) - LS-C80055 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.

Anti-MLX / TCFL4 Antibody (Internal, AP) - LS-C206741 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLX / TCFL4 Antibody (N-Terminus) - LS-C80293 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.

Anti-MLX / TCFL4 Antibody (aa197-246) - LS-C81653 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-MLX / TCFL4 Antibody (aa180-229) - LS-C112185 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MLX antibody LS-C112185 Western blot of MCF7 cell lysate.
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