MLX

Gene Symbol MLX
Entrez Gene 6945
Alt Symbol MAD7, MXD7, TCFL4, bHLHd13
Species Human
Gene Type protein-coding
Description MLX, MAX dimerization protein
Other Description BigMax protein|MAX-like bHLHZIP protein|class D basic helix-loop-helix protein 13|max-like protein X|transcription factor-like protein 4
Swissprots Q9H2V1 Q53XM6 Q9H2V2 B2RD73 B2RAV8 Q9H2V0 Q96FL2 Q9NXN3 Q9UH92 A8K2J3
Accessions EAW60841 EAW60842 EAW60843 EAW60844 EAW60845 Q9UH92 AA024982 AB209235 BAD92472 AF203978 AAF14638 AF213666 AAG40145 AF213667 AAG40146 AF213668 AAG40147 AK000150 BAA90977 AK290258 BAF82947 AK296114 BAG58863 AK303221 BAG64308 AK309628 AK314378 BAG37005 AK315432 BAG37820 BC010689 AAH10689 BC014537 BE907687 BI517590 BQ186038 BT009812 AAP88814 NM_170607 NP_733752 NM_198204 NP_937847 NM_198205 NP_937848
Function Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Subcellular Location Isoform Gamma: Nucleus. Note=Found predominantly in the nucleus.
Tissue Specificity Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung. {ECO:0000269|PubMed:10593926}.
Top Pathways Non-alcoholic fatty liver disease (NAFLD)

Mlx CRISPR/Cas9 KO Plasmid (h) - sc-403499 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mlx HDR Plasmid (h) - sc-403499-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mlx Double Nickase Plasmid (h) - sc-403499-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mlx Double Nickase Plasmid (h2) - sc-403499-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mlx CRISPR Activation Plasmid (h) - sc-403499-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mlx CRISPR Activation Plasmid (h2) - sc-403499-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mlx Lentiviral Activation Particles (h) - sc-403499-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mlx Lentiviral Activation Particles (h2) - sc-403499-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mlx siRNA (h) - sc-38081 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Mlx shRNA Plasmid (h) - sc-38081-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Mlx shRNA (h) Lentiviral Particles - sc-38081-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLX RNAi - H00006945-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MLX RNAi - H00006945-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MLX RNAi - H00006945-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU114471 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14411 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14411 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MLX siRNA (Human) - CRH4763 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MLX (NM_198205.1) - SHH342692 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MLX(NM_198204.1) - SHH192683 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MLX(NM_198205.1) - SHH192737 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MLX(NM_170607.2) - SHH192755 from Creative biogene

Category siRNA
Species Reactivities Human

Human MLX siRNA - orb265265 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MLX shRNA Plasmid (Human) - CHH4763 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MLX miRNA 3'UTR clone - MiUTR1H-06336 from Creative biogene

Species Reactivities Human
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