MLX
| Gene Symbol | MLX |
|---|---|
| Entrez Gene | 6945 |
| Alt Symbol | MAD7, MXD7, TCFL4, bHLHd13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MLX, MAX dimerization protein |
| Other Description | BigMax protein|MAX-like bHLHZIP protein|class D basic helix-loop-helix protein 13|max-like protein X|transcription factor-like protein 4 |
| Swissprots | Q9H2V1 Q53XM6 Q9H2V2 B2RD73 B2RAV8 Q9H2V0 Q96FL2 Q9NXN3 Q9UH92 A8K2J3 |
| Accessions | EAW60841 EAW60842 EAW60843 EAW60844 EAW60845 Q9UH92 AA024982 AB209235 BAD92472 AF203978 AAF14638 AF213666 AAG40145 AF213667 AAG40146 AF213668 AAG40147 AK000150 BAA90977 AK290258 BAF82947 AK296114 BAG58863 AK303221 BAG64308 AK309628 AK314378 BAG37005 AK315432 BAG37820 BC010689 AAH10689 BC014537 BE907687 BI517590 BQ186038 BT009812 AAP88814 NM_170607 NP_733752 NM_198204 NP_937847 NM_198205 NP_937848 |
| Function | Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Subcellular Location | Isoform Gamma: Nucleus. Note=Found predominantly in the nucleus. |
| Tissue Specificity | Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung. {ECO:0000269|PubMed:10593926}. |
| Top Pathways | Non-alcoholic fatty liver disease (NAFLD) |
Mlx CRISPR/Cas9 KO Plasmid (h) - sc-403499 from Santa Cruz Biotechnology
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Mlx HDR Plasmid (h) - sc-403499-HDR from Santa Cruz Biotechnology
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Mlx Double Nickase Plasmid (h) - sc-403499-NIC from Santa Cruz Biotechnology
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Mlx Double Nickase Plasmid (h2) - sc-403499-NIC-2 from Santa Cruz Biotechnology
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Mlx CRISPR Activation Plasmid (h) - sc-403499-ACT from Santa Cruz Biotechnology
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Mlx CRISPR Activation Plasmid (h2) - sc-403499-ACT-2 from Santa Cruz Biotechnology
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Mlx Lentiviral Activation Particles (h) - sc-403499-LAC from Santa Cruz Biotechnology
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Mlx Lentiviral Activation Particles (h2) - sc-403499-LAC-2 from Santa Cruz Biotechnology
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Mlx siRNA (h) - sc-38081 from Santa Cruz Biotechnology
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Mlx shRNA Plasmid (h) - sc-38081-SH from Santa Cruz Biotechnology
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Mlx shRNA (h) Lentiviral Particles - sc-38081-V from Santa Cruz Biotechnology
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MLX RNAi - H00006945-R03 from Novus Biologicals
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MLX RNAi - H00006945-R01 from Novus Biologicals
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MLX RNAi - H00006945-R02 from Novus Biologicals
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MISSION® esiRNA - EHU114471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14411 from Sigma-Aldrich
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MLX siRNA (Human) - CRH4763 from Cohesion Biosciences
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shRNA set against Human MLX (NM_198205.1) - SHH342692 from Creative biogene
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shRNA set against Human MLX(NM_198204.1) - SHH192683 from Creative biogene
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shRNA set against Human MLX(NM_198205.1) - SHH192737 from Creative biogene
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shRNA set against Human MLX(NM_170607.2) - SHH192755 from Creative biogene
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Human MLX siRNA - orb265265 from Biorbyt
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MLX shRNA Plasmid (Human) - CHH4763 from Cohesion Biosciences
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MLX miRNA 3'UTR clone - MiUTR1H-06336 from Creative biogene
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