| Gene Symbol | CCL23 |
|---|---|
| Entrez Gene | 6368 |
| Alt Symbol | CK-BETA-8, CKb8, Ckb-8, Ckb-8-1, MIP-3, MIP3, MPIF-1, SCYA23, hmrp-2a |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 23 |
| Other Description | C-C motif chemokine 23|C6 beta-chemokine|macrophage inflammatory protein 3|myeloid progenitor inhibitory factor 1|small inducible cytokine subfamily A (Cys-Cys), member 23 |
| Swissprots | B7ZKQ3 P55773 Q52LD4 O75950 O00174 |
| Accessions | AAC63326 AAC63327 EAW80103 EAW80104 P55773 BC093970 AAH93970 BC143310 AAI43311 BQ026575 U58913 AAD10846 U67128 AAD00161 U85767 AAB51134 XR_429910 XR_430786 NM_005064 NP_005055 NM_145898 NP_665905 |
| Function | Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. {ECO:0000269|PubMed:15905581}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. {ECO:0000269|PubMed:15905581}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |