| Gene Symbol | CCL23 |
|---|---|
| Entrez Gene | 6368 |
| Alt Symbol | CK-BETA-8, CKb8, Ckb-8, Ckb-8-1, MIP-3, MIP3, MPIF-1, SCYA23, hmrp-2a |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 23 |
| Other Description | C-C motif chemokine 23|C6 beta-chemokine|macrophage inflammatory protein 3|myeloid progenitor inhibitory factor 1|small inducible cytokine subfamily A (Cys-Cys), member 23 |
| Swissprots | B7ZKQ3 P55773 Q52LD4 O75950 O00174 |
| Accessions | AAC63326 AAC63327 EAW80103 EAW80104 P55773 BC093970 AAH93970 BC143310 AAI43311 BQ026575 U58913 AAD10846 U67128 AAD00161 U85767 AAB51134 XR_429910 XR_430786 NM_005064 NP_005055 NM_145898 NP_665905 |
| Function | Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. {ECO:0000269|PubMed:15905581}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. {ECO:0000269|PubMed:15905581}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
CCL23 CRISPR/Cas9 KO Plasmid (h) - sc-408772 from Santa Cruz Biotechnology
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CCL23 HDR Plasmid (h) - sc-408772-HDR from Santa Cruz Biotechnology
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CCL23 Double Nickase Plasmid (h) - sc-408772-NIC from Santa Cruz Biotechnology
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CCL23 Double Nickase Plasmid (h2) - sc-408772-NIC-2 from Santa Cruz Biotechnology
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CCL23 CRISPR Activation Plasmid (h) - sc-408772-ACT from Santa Cruz Biotechnology
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CCL23 CRISPR Activation Plasmid (h2) - sc-408772-ACT-2 from Santa Cruz Biotechnology
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CCL23 Lentiviral Activation Particles (h) - sc-408772-LAC from Santa Cruz Biotechnology
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CCL23 Lentiviral Activation Particles (h2) - sc-408772-LAC-2 from Santa Cruz Biotechnology
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CCL23 siRNA (h) - sc-45634 from Santa Cruz Biotechnology
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CCL23 shRNA Plasmid (h) - sc-45634-SH from Santa Cruz Biotechnology
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CCL23 shRNA (h) Lentiviral Particles - sc-45634-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU121021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5609 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5609 from Sigma-Aldrich
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CCL23 siRNA (Human) - CRH4300 from Cohesion Biosciences
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CCL23 - MBS8240939 from MyBioSource
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shRNA set against Human CCL23 (NM_005064.3) - SHH257589 from Creative biogene
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shRNA set against Human CCL23(NM_145898.1) - SHG150893 from Creative biogene
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shRNA set against Human CCL23(NM_005064.3) - SHG150947 from Creative biogene
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Human CCL23 siRNA - orb264802 from Biorbyt
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CCL23 shRNA Plasmid (Human) - CHH4300 from Cohesion Biosciences
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CCL23 miRNA 3'UTR clone - MiUTR1H-01798 from Creative biogene
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CCL23 miRNA 3'UTR clone - MiUTR1H-01799 from Creative biogene
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