Gene Symbol | CCL23 |
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Entrez Gene | 6368 |
Alt Symbol | CK-BETA-8, CKb8, Ckb-8, Ckb-8-1, MIP-3, MIP3, MPIF-1, SCYA23, hmrp-2a |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 23 |
Other Description | C-C motif chemokine 23|C6 beta-chemokine|macrophage inflammatory protein 3|myeloid progenitor inhibitory factor 1|small inducible cytokine subfamily A (Cys-Cys), member 23 |
Swissprots | B7ZKQ3 P55773 Q52LD4 O75950 O00174 |
Accessions | AAC63326 AAC63327 EAW80103 EAW80104 P55773 BC093970 AAH93970 BC143310 AAI43311 BQ026575 U58913 AAD10846 U67128 AAD00161 U85767 AAB51134 XR_429910 XR_430786 NM_005064 NP_005055 NM_145898 NP_665905 |
Function | Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. {ECO:0000269|PubMed:15905581}. |
Subcellular Location | Secreted. |
Tissue Specificity | High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. {ECO:0000269|PubMed:15905581}. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
Active human Macrophage Inflammatory Protein 3 full length protein - ab138793 from Abcam
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Active human Macrophage Inflammatory Protein 3 full length protein - ab192098 from Abcam
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Active Macrophage Inflammatory Protein 3 full length protein - ab9931 from Abcam
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Human Macrophage Inflammatory Protein 3 full length protein - ab193748 from Abcam
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Human Macrophage Inflammatory Protein 3 full length protein - ab56273 from Abcam
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Recombinant Human CCL23/Ck beta 8-1/MIP3 Protein - NBP2-35021 from Novus Biologicals
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CCL23/Ck beta 8-1/MIP3 Recombinant Protein - H00006368-P01 from Novus Biologicals
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CCL23/Ck beta 8-1/MIP3 Recombinant Protein - P3653 from Novus Biologicals
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MIP3 Recombinant Protein (Active) - GTX48143-PRO from GeneTex
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Recombinant Human CCL23/MPIF-1 - 371-MP-025 from R&D Systems
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Recombinant Human CCL23/MPIF-1, CF - 371-MP-025/CF from R&D Systems
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Recombinant Human CCL23/MPIF-1 (aa 46-120) - 131-M1-025 from R&D Systems
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Recombinant Human CCL23/MPIF-1 (aa 46-120), CF - 131-M1-025/CF from R&D Systems
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Recombinant Human CCL23/Ck beta 8-1 (aa 46-137) - 508-CK-025 from R&D Systems
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Recombinant Human CCL23/Ck beta 8-1 (aa 46-137), CF - 508-CK-025/CF from R&D Systems
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Human Chemokine Protein Sampler Pack (Allergy Research) - SMPK7 from R&D Systems
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MIP 3 Protein (OPPA01804) - OPPA01804 from Aviva Systems Biology
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Human CCL23 (His Tag) protein - orb232240 from Biorbyt
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Human CCL23 protein - orb138333 from Biorbyt
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Human MIP 3 protein - orb168839 from Biorbyt
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Human CCL23 protein (His Tag) - orb138332 from Biorbyt
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Human MIP 3 protein - orb168838 from Biorbyt
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Human CCL23 protein - orb49261 from Biorbyt
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MIP3 protein - 30R-AM055 from Fitzgerald
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Human MPIF1 Protein - abx068127 from Abbexa
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