| Gene Symbol | CLDN7 |
|---|---|
| Entrez Gene | 1366 |
| Alt Symbol | CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | claudin 7 |
| Other Description | claudin-7|clostridium perfringens enterotoxin receptor-like 2 |
| Swissprots | Q9BVN0 Q7Z4Y7 Q6IPN3 B2R9X7 O95471 D3DTP0 |
| Accessions | EAW90228 EAW90229 O95471 AF093823 AAP97219 AJ011497 CAA09626 AK225418 AK313958 BAG36674 BC001055 AAH01055 BC071844 AAH71844 BM818537 BT006829 AAP35475 CV575841 NM_001185022 NP_001171951 NM_001185023 NP_001171952 NM_001307 NP_001298 |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co- localizes with EPCAM at the lateral cell membrane and tight junction. |
| Tissue Specificity | Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. {ECO:0000269|PubMed:12673207, ECO:0000269|PubMed:14502431}. |
| Top Pathways | Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C |