| Gene Symbol |
TFAP2C
|
| Entrez Gene |
7022
|
| Alt Symbol |
AP2-GAMMA, ERF1, TFAP2G, hAP-2g
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
|
| Other Description |
activating enhancer-binding protein 2 gamma|estrogen receptor factor 1|transcription factor AP-2 gamma|transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)|transcription factor ERF-1
|
| Swissprots |
O00685 Q9P1X2 Q86V30 B4DWK3 O00730 Q8IVB6 Q92754
|
| Accessions |
AAN37906 BAC11805 CAC86997 EAW75532 Q92754 AK301572 BAG63065 AK314272 BAG36933 BC035664 AAH35664 BC051829 AAH51829 U85658 AAC51305 X95693 CAA64989 NM_003222 NP_003213
|
| Function |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:24413532}.
|