Gene Symbol | TFAP2C |
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Entrez Gene | 7022 |
Alt Symbol | AP2-GAMMA, ERF1, TFAP2G, hAP-2g |
Species | Human |
Gene Type | protein-coding |
Description | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) |
Other Description | activating enhancer-binding protein 2 gamma|estrogen receptor factor 1|transcription factor AP-2 gamma|transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)|transcription factor ERF-1 |
Swissprots | O00685 Q9P1X2 Q86V30 B4DWK3 O00730 Q8IVB6 Q92754 |
Accessions | AAN37906 BAC11805 CAC86997 EAW75532 Q92754 AK301572 BAG63065 AK314272 BAG36933 BC035664 AAH35664 BC051829 AAH51829 U85658 AAC51305 X95693 CAA64989 NM_003222 NP_003213 |
Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:24413532}. |
AP-2γ CRISPR/Cas9 KO Plasmid (h) - sc-400884 from Santa Cruz Biotechnology
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AP-2γ HDR Plasmid (h) - sc-400884-HDR from Santa Cruz Biotechnology
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AP-2γ Double Nickase Plasmid (h) - sc-400884-NIC from Santa Cruz Biotechnology
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AP-2γ Double Nickase Plasmid (h2) - sc-400884-NIC-2 from Santa Cruz Biotechnology
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AP-2γ CRISPR Activation Plasmid (h) - sc-400884-ACT from Santa Cruz Biotechnology
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AP-2γ CRISPR Activation Plasmid (h2) - sc-400884-ACT-2 from Santa Cruz Biotechnology
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AP-2γ Lentiviral Activation Particles (h) - sc-400884-LAC from Santa Cruz Biotechnology
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AP-2γ Lentiviral Activation Particles (h2) - sc-400884-LAC-2 from Santa Cruz Biotechnology
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AP-2γ siRNA (h) - sc-29696 from Santa Cruz Biotechnology
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AP-2γ shRNA Plasmid (h) - sc-29696-SH from Santa Cruz Biotechnology
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AP-2γ shRNA (h) Lentiviral Particles - sc-29696-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU019581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21246 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21246 from Sigma-Aldrich
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TFAP2C siRNA (Human) - CRH4797 from Cohesion Biosciences
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AP-2 gamma RNAi - H00007022-R01 from Novus Biologicals
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TFAP2C - MBS8211579 from MyBioSource
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shRNA set against Human TFAP2C (NM_003222.3) - SHH426096 from Creative biogene
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shRNA set against Human TFAP2C(NM_003222.3) - SHL066576 from Creative biogene
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TFAP2C shRNA Plasmid (Human) - CHH4797 from Cohesion Biosciences
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TFAP2C miRNA 3'UTR clone - MiUTR1H-10337 from Creative biogene
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