MRAP

Gene Symbol MRAP
Entrez Gene 56246
Alt Symbol B27, C21orf61, FALP, FGD2, GCCD2
Species Human
Gene Type protein-coding
Description melanocortin 2 receptor accessory protein
Other Description fat cell-specific low molecular weight protein|fat tissue-specific low MW protein|melanocortin-2 receptor accessory protein
Swissprots Q8WXC2 Q8TDB7 Q8WXC1 Q5EBR3 Q8TCY5
Accessions EAX09878 EAX09879 EAX09880 Q8TCY5 AF454915 AAL51048 AF454916 AAL51049 AF483549 AAL86908 AY079152 AAL80042 BC062721 AAH62721 HQ257956 ADR82710 XM_006724028 XP_006724091 NM_178817 NP_848932 NM_206898 NP_996781 NM_001285394 NP_001272323
Function Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. {ECO:0000269|PubMed:15654338, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm. {ECO:0000269|PubMed:20371771}.
Tissue Specificity Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues. {ECO:0000269|PubMed:15654338}.

MRAP (T-18) - sc-83733 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-MRAP antibody - ab103319 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab103319 stained U-87 MG cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab103319 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MRAP antibody - ab168120 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MRAP antibody (ab168120) at 1 µg/mlLane 1 : MRAP transfected 293T cell lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG

Anti-MRAP Antibody (aa14-44, AP) - LS-C263480 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MRAP Antibody (aa14-44, APC) - LS-C263481 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MRAP Antibody (aa14-44, Biotin) - LS-C263482 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MRAP Antibody (aa14-44, FITC) - LS-C263483 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MRAP Antibody (aa14-44, PE) - LS-C263485 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MRAP Antibody (aa14-44, Azide-free, HRP) - LS-C263484 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MRAP Antibody - LS-C309054 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MRAP Antibody (aa14-44) - LS-C323094 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MRAP Antibody (N-Terminus) - LS-C201501 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human OVCAR-3. MRAP antibody dilution 1.0 ug/ml.

Anti-MRAP Antibody (aa7-36) - LS-C164618 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of MRAP Antibody in 293 cell line lysates (35 ug/lane). MRAP (arrow) was detected using the purified antibody.

FGD2 Antibody - NBP1-80600 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: FGD2 Antibody [NBP1-80600] - Staining of human kidney shows strong cytoplasmic positivity in renal tubules.

MRAP Antibody - NBP1-88942 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunohistochemistry: MRAP Antibody [NBP1-88942] - Immunohistochemical staining of human rectum shows strong granular positivity in glandular cells.

MRAP Antibody - NBP1-88941 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: MRAP Antibody [NBP1-88941] - Immunohistochemical staining of human rectum shows strong positivity in glandular cells.

MRAP Antibody - H00056246-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: MRAP Antibody [H00056246-B01] - analysis of MRAP expression in transfected 293T cell line by MRAP MaxPab polyclonal antibody. Lane 1: MRAP transfected lysate (18.92 KDa). Lane 2: Non-transfected lysate.

MRAP Antibody - H00056246-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: MRAP Antibody [H00056246-B01P] - Analysis of MRAP expression in transfected 293T cell line by MRAP polyclonal antibody. Lane 1: MRAP transfected lysate(18.92 KDa). Lane 2: Non-transfected lysate.

MRAP Antibody (3D12) - H00056246-M01A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 3D12

LRPAP1 Polyclonal Antibody - bs-6055R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-MRAP, (C-terminal) antibody produced in mouse - SAB1403312 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 3D12
<B>Immunoblotting</B><BR/>Monoclonal Anti-MRAP: <B>Cat. No. SAB1403312</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.6 kDa using immunogen protein lysate.

Anti-MRAP antibody produced in rabbit - HPA011024 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MRAP: <B>Cat. No. HPA011024</B>: Immunohistochemical staining of human rectum shows strong positivity in glandular cells.

Anti-MRAP antibody produced in mouse - SAB1407734 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MRAP: <B>Cat. No. SAB1407734</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~18.9 kDa using MRAP transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

MRAP Antibody - N-terminal region (ARP45926_P050) - ARP45926_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MRAP-Antibody-N-term - AP9980a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of MRAP Antibody (N-term) (Cat. #AP9980a) in 293 cell line lysates (35ug/lane). MRAP (arrow) was detected using the purified Pab.
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