MRAP

Gene Symbol	MRAP
Entrez Gene	56246
Alt Symbol	B27, C21orf61, FALP, FGD2, GCCD2
Species	Human
Gene Type	protein-coding
Description	melanocortin 2 receptor accessory protein
Other Description	fat cell-specific low molecular weight protein|fat tissue-specific low MW protein|melanocortin-2 receptor accessory protein
Swissprots	Q8WXC2 Q8TDB7 Q8WXC1 Q5EBR3 Q8TCY5
Accessions	EAX09878 EAX09879 EAX09880 Q8TCY5 AF454915 AAL51048 AF454916 AAL51049 AF483549 AAL86908 AY079152 AAL80042 BC062721 AAH62721 HQ257956 ADR82710 XM_006724028 XP_006724091 NM_178817 NP_848932 NM_206898 NP_996781 NM_001285394 NP_001272323
Function	Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. {ECO:0000269|PubMed:15654338, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm. {ECO:0000269|PubMed:20371771}.
Tissue Specificity	Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues. {ECO:0000269|PubMed:15654338}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MRAP 293T Cell Transient Overexpression Lysate(Denatured) - H00056246-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

MRAP overexpression lysate - LY404158 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

Human MRAP / FLAP HEK293 Cell Lysate (WB positive control) - 15444-H01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human MRAP Human Cells Transfected Lysate (positive control) (denatured) - orb233022 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

MRAP Overexpression Lysate (Native) - NBP2-04518 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

MRAP Overexpression Lysate (Denatured) - H00056246-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

MRAP Overexpression Lysate (Denatured) - H00056246-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human MRAP Knockdown Stable Cell Line - CSC-DC009697 from Creative biogene Category Cell Line Species Human

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