| Gene Symbol | MRAP |
|---|---|
| Entrez Gene | 56246 |
| Alt Symbol | B27, C21orf61, FALP, FGD2, GCCD2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | melanocortin 2 receptor accessory protein |
| Other Description | fat cell-specific low molecular weight protein|fat tissue-specific low MW protein|melanocortin-2 receptor accessory protein |
| Swissprots | Q8WXC2 Q8TDB7 Q8WXC1 Q5EBR3 Q8TCY5 |
| Accessions | EAX09878 EAX09879 EAX09880 Q8TCY5 AF454915 AAL51048 AF454916 AAL51049 AF483549 AAL86908 AY079152 AAL80042 BC062721 AAH62721 HQ257956 ADR82710 XM_006724028 XP_006724091 NM_178817 NP_848932 NM_206898 NP_996781 NM_001285394 NP_001272323 |
| Function | Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. {ECO:0000269|PubMed:15654338, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm. {ECO:0000269|PubMed:20371771}. |
| Tissue Specificity | Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues. {ECO:0000269|PubMed:15654338}. |