MRAP

Gene Symbol	MRAP
Entrez Gene	56246
Alt Symbol	B27, C21orf61, FALP, FGD2, GCCD2
Species	Human
Gene Type	protein-coding
Description	melanocortin 2 receptor accessory protein
Other Description	fat cell-specific low molecular weight protein|fat tissue-specific low MW protein|melanocortin-2 receptor accessory protein
Swissprots	Q8WXC2 Q8TDB7 Q8WXC1 Q5EBR3 Q8TCY5
Accessions	EAX09878 EAX09879 EAX09880 Q8TCY5 AF454915 AAL51048 AF454916 AAL51049 AF483549 AAL86908 AY079152 AAL80042 BC062721 AAH62721 HQ257956 ADR82710 XM_006724028 XP_006724091 NM_178817 NP_848932 NM_206898 NP_996781 NM_001285394 NP_001272323
Function	Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. {ECO:0000269|PubMed:15654338, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm. {ECO:0000269|PubMed:20371771}.
Tissue Specificity	Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues. {ECO:0000269|PubMed:15654338}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MRAP full length protein - ab163366 from Abcam Category Protein Source Wheat germ Species Human

Human MRAP protein fragment - ab163367 from Abcam Category Protein Source Wheat germ Species Human

FGD2 Antibody Blocking Peptide - LS-E2259 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MRAP Antibody Blocking Peptide - LS-E10433 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MRAP Protein - H00056246-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MRAP Protein - H00056246-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human FGD2 Protein - H00221472-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MRAP-Antibody-N-term-Blocking-Peptide - BP9980a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MRAP (Fc Tag) protein - orb232372 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Species Human

MRAP - H00056246-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MRAP - H00056246-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MRAP - H00056246-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MRAP - H00056246-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Human MRAP / FLAP Protein (Fc Tag) - 15444-H01H-20 from Sino Biological Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

Recombinant Vaccinia virus Protein C21/B27 (B27R) - CSB-YP322733VAA CSB-EP322733VAA CSB-BP322733VAA CSB-MP322733VAA from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

MRAP (transcript variant 2) - TP318683 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human MRAP Protein, Fc-tagged - MRAP-683H from Creative Biomart Category Protein Source HEK293 Species Human

MRAP Recombinant Protein Antigen - NBP1-88941PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FGD2 Protein - NBP1-80600PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

MRAP Peptide, Human - M34GP09697H from Creative Peptides Category Peptide Source Synthetic. Species Human

FGD2 Recombinant Protein Antigen - NBP2-48944PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

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