Gene Symbol |
ISL1
|
Entrez Gene |
3670
|
Alt Symbol |
ISLET1, Isl-1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
ISL LIM homeobox 1
|
Other Description |
ISL1 transcription factor, LIM/homeodomain|insulin gene enhancer protein ISL-1|islet-1
|
Swissprots |
P61371
|
Accessions |
EAW54861 P61371 AK290742 BAF83431 BC017027 BC031213 AAH31213 BM680522 DQ891558 ABM82484 DQ894746 ABM85672 EU176619 ABW03420 S70721 AAD14064 U07559 AAA81946 XM_011543380 XP_011541682 NM_002202 NP_002193
|
Function |
Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity). {ECO:0000250}.
|
Subcellular Location |
Nucleus.
|
Tissue Specificity |
Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
|
Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|