ISL1

Gene Symbol ISL1
Entrez Gene 3670
Alt Symbol ISLET1, Isl-1
Species Human
Gene Type protein-coding
Description ISL LIM homeobox 1
Other Description ISL1 transcription factor, LIM/homeodomain|insulin gene enhancer protein ISL-1|islet-1
Swissprots P61371
Accessions EAW54861 P61371 AK290742 BAF83431 BC017027 BC031213 AAH31213 BM680522 DQ891558 ABM82484 DQ894746 ABM85672 EU176619 ABW03420 S70721 AAD14064 U07559 AAA81946 XM_011543380 XP_011541682 NM_002202 NP_002193
Function Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Tissue Specificity Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
Top Pathways Signaling pathways regulating pluripotency of stem cells

Islet-1 (B-1) - sc-390793 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Islet-1 (B-1): sc-390793. Western blot analysis of Islet-1 expression in K-562 whole cell lysate.

Islet-1 (K-20) - sc-23590 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Islet-1 (K-20): sc-23590. Western blot analysis of Islet-1 expression in HeLa (A) and Jurkat (B) nuclear extracts.

Islet-1/2 (H-120) - sc-30200 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Islet-1/2 (H-120): sc-30200. Western blot analysis of Islet-1/2 expression in SH-SY5Y nuclear extract.

Islet-1 (3B8) - sc-101072 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Islet-1 (3B8): sc-101072. Western blot analysis of Islet-1 expression in K-562 whole cell lysate.

Anti-Islet 1 antibody [1B1] - ab86501 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B1
Confocal immunofluorescence analysis of HEK293 cells trasfected with full-length Islet 1-hIgGFc using ab86501 at 1/150 dilution (green). Blue: DRAQ5 fluorescent DNA dye.

Anti-Islet 1 antibody [1H9] - ab86472 from Abcam

Prices $392.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H9
Anti-Islet 1 antibody [1H9] (ab86472) at 1/500 dilution + HEK293 cells transfected with full length Islet 1 (aa1-349)-hIgGFc

Anti-Islet 1 antibody [EP4182] - ab109517 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4182
IF/ICC image of ab109517 stained U-87 MG cells.

Anti-Islet 1 antibody [EPR10362] - ab178400 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10362
All lanes : Anti-Islet 1 antibody [EPR10362] (ab178400) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysateLane 3 : Jurkat cell lysateLane 4 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilutiondeveloped using the ECL technique

Anti-Islet 1 antibody - C-terminal - ab200101 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Islet 1 antibody - C-terminal (ab200101) at 1/1000 dilutionLane 1 : Mouse brain total cell extractLane 2 : Mouse thymus total cell extract

Anti-Islet 1 antibody - Neural Stem Cell Marker - ab20670 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Dorsal root ganglion explants were dissected from 16 day-old rat embryos and cultured for 6 hours in vitro with Neurobasal Medium containing B27 supplement.     Nuclei stained positive for anti-Islet 1 antibody ab20670 at 2µg/ml. As would be expected, not all cells in this preparation were Islet 1-positive. Pre-incubation of ab20670 with the immunizing peptide ab21996 resulted in complete blocking of the antibody.Green = ab20670Blue = To-pro-3 nuclear stainThe level of magnification is different in each image.    

Anti-ISLET-1 / ISL1 Antibody (Internal, clone EP4182) IHC-plus™ - LS-B11657 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EP4182
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-ISLET-1 / ISL1 Antibody (clone 1H9) IHC-plus™ - LS-B6125 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 1H9
Anti-ISL1 / Islet 1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6125 dilution 1:200.

Anti-ISLET-1 / ISL1 Antibody (aa170-183) - LS-C8296 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (aa63-160, Azide-free) - LS-C130304 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-ISLET-1 / ISL1 Antibody (Internal) - LS-C209929 from LifeSpan Bioscience

Prices $405.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (Internal) - LS-C210131 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (Internal) - LS-C210132 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (aa102-151) - LS-C79999 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-ISLET-1 / ISL1 Antibody (aa156-185, AP) - LS-C260419 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (aa156-185, Azide-free, HRP) - LS-C260422 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (aa156-185, APC) - LS-C260420 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (aa156-185, Biotin) - LS-C260421 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (aa156-185, FITC) - LS-C260423 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (aa156-185, PE) - LS-C260424 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ISLET-1 / ISL1 Antibody (aa241-290) - LS-C201232 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Breast Tumor. ISL1 antibody dilution 1.0 ug/ml.
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