| Gene Symbol |
ULBP3
|
| Entrez Gene |
79465
|
| Alt Symbol |
RAET1N
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UL16 binding protein 3
|
| Other Description |
ALCAN-gamma|N2DL-3|NKG2D ligand 3|NKG2DL3|UL16-binding protein 3|retinoic acid early transcript 1N
|
| Swissprots |
Q5VY82 Q9BZM4 Q8IZX5 Q8TE75
|
| Accessions |
EAW47772 Q9BZM4 AB052908 BAB61050 AF304379 AAK13083 AF346596 AAN40839 AK297815 BAG60153 AK302076 BAG63465 AK315275 BAG37687 AY027538 AAK13049 BC098127 AAH98127 XM_005267137 XP_005267194 NM_024518 NP_078794
|
| Function |
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. {ECO:0000269|PubMed:11777960}.
|
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|