TDP2

Gene Symbol TDP2
Entrez Gene 51567
Alt Symbol AD022, EAP2, EAPII, TTRAP, dJ30M3.3, hTDP2
Species Human
Gene Type protein-coding
Description tyrosyl-DNA phosphodiesterase 2
Other Description 5'-Tyr-DNA phosphodiesterase|5'-tyrosyl-DNA phosphodiesterase|ETS1-associated protein 2|ETS1-associated protein II|TRAF and TNF receptor associated protein|TRAF and TNF receptor-associated protein|VPg unlinkase|tyr-DNA phosphodiesterase 2|tyrosyl-RNA phosphodiesterase
Swissprots Q2TBE2 Q5JYM0 O95551 B4DKL8 B4DQ95 Q9NYY9 Q7Z6U5 Q9NUK5
Accessions AAT09764 EAW55458 EAW55459 O95551 AF201687 AAG35600 AF223469 AAF64144 AJ269473 CAB92966 AJ420495 AK002168 BAA92119 AK296623 BAG59230 AK298699 BAG60857 AK308836 BC017553 AAH17553 BC110375 AAI10376 EU446614 ABZ92143 JN104587 AFK13123 XR_926244 NM_016614 NP_057698
Function DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'- tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'- tyrosyl-DNA phosphodiesterase in cells. Also acts as a 5'-tyrosyl- RNA phosphodiesterase following picornavirus infection: its activi
Subcellular Location Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10764746}.

TDP2 (H-300) - sc-135214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TDP2 (H-300): sc-135214. Western blot analysis of TDP2 expression in non-transfected: sc-110760 (A) and human EAPII transfected: sc-112226 (B) 293 whole cell lysates.

TDP2 (K-13) - sc-47871 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TDP2 (H-6) - sc-377280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TDP2 (H-6): sc-377280. Western blot analysis of TDP2 expression in non-transfected: sc-117752 (A) and human TDP2 transfected: sc-370234 (B) 293T whole cell lysates and mouse testis tissue extract (C).

TDP2 (M-300) - sc-135213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TDP2 (M-300): sc-135213. Western blot analysis of TDP2 expression in non-transfected: sc-117752 (A) and human TDP2 transfected: sc-370234 (B) 293T whole cell lysates.

TDP2 (16) - sc-130314 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-ETS1 associated protein II antibody - ab99279 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue labelling ETS1 associated protein II with ab99279 at 1/200 (1µg/mg). Detection: DAB.

Anti-ETS1 associated protein II antibody - ab33246 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ETS1 associated protein II antibody (ab33246) at 1/1000 dilutionLane 1 : 5ug of Purified ETS1 associated protein.Lane 2 : 30 ug of OV2008 human ovarian cancer cell line, whole cell lysate.

Anti-ETS1 associated protein II antibody - ab126945 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ETS1 associated protein II antibody (ab126945) at 1/3000 dilution + HCT116 whole cell lysate at 30 µg

Anti-ETS1 associated protein II antibody [16] - ab67458 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 16
Anti-ETS1 associated protein II antibody [16] (ab67458) at 1/1000 dilution + human recombinant ETS1 associated protein II.

Anti-ETS1 associated protein II antibody [EPR11932] - ab176341 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11932
All lanes : Anti-ETS1 associated protein II antibody [EPR11932] (ab176341) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : K562 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-TDP2 / TTRAP Antibody IHC-plus™ - LS-B10866 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TDP2 / TTRAP antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10866 concentration 7.5 ug/ml.

Anti-TDP2 / TTRAP Antibody (aa50-100) - LS-C289458 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human TDP2 by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-TDP2 used at a dilution of 1:200 (1 ug/mg).

Anti-TDP2 / TTRAP Antibody (clone 3D11) - LS-C134070 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D11
Immunoperoxidase of monoclonal antibody to TTRAP on formalin-fixed paraffin-embedded human testis. [antibody concentration 1.5 ug/ml]

Anti-TDP2 / TTRAP Antibody (aa11-28) IHC-plus™ - LS-B1624 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TDP2 / TTRAP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1624 concentration 5 ug/ml.

Anti-TDP2 / TTRAP Antibody (aa246-272) - LS-C167602 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
EAPII Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TDP2 / TTRAP Antibody (C-Terminus) - LS-C53366 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TDP2 / TTRAP Antibody - LS-C83451 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TDP2 / TTRAP Antibody (aa246-272, PE) - LS-C234841 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP2 / TTRAP Antibody (aa246-272, AP) - LS-C246869 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP2 / TTRAP Antibody - LS-C137530 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-TDP2 / TTRAP Antibody (aa246-272, APC) - LS-C246870 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP2 / TTRAP Antibody (aa246-272, FITC) - LS-C246871 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP2 / TTRAP Antibody (aa246-272, Biotin) - LS-C246872 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP2 / TTRAP Antibody (aa246-272, Azide-free, HRP) - LS-C249887 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP2 / TTRAP Antibody (aa253-281) - LS-C321001 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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