| Gene Symbol |
TDP2
|
| Entrez Gene |
51567
|
| Alt Symbol |
AD022, EAP2, EAPII, TTRAP, dJ30M3.3, hTDP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tyrosyl-DNA phosphodiesterase 2
|
| Other Description |
5'-Tyr-DNA phosphodiesterase|5'-tyrosyl-DNA phosphodiesterase|ETS1-associated protein 2|ETS1-associated protein II|TRAF and TNF receptor associated protein|TRAF and TNF receptor-associated protein|VPg unlinkase|tyr-DNA phosphodiesterase 2|tyrosyl-RNA phosphodiesterase
|
| Swissprots |
Q2TBE2 Q5JYM0 O95551 B4DKL8 B4DQ95 Q9NYY9 Q7Z6U5 Q9NUK5
|
| Accessions |
AAT09764 EAW55458 EAW55459 O95551 AF201687 AAG35600 AF223469 AAF64144 AJ269473 CAB92966 AJ420495 AK002168 BAA92119 AK296623 BAG59230 AK298699 BAG60857 AK308836 BC017553 AAH17553 BC110375 AAI10376 EU446614 ABZ92143 JN104587 AFK13123 XR_926244 NM_016614 NP_057698
|
| Function |
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'- tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'- tyrosyl-DNA phosphodiesterase in cells. Also acts as a 5'-tyrosyl- RNA phosphodiesterase following picornavirus infection: its activi
|
| Subcellular Location |
Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation.
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| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10764746}.
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