| Gene Symbol |
COTL1
|
| Entrez Gene |
23406
|
| Alt Symbol |
CLP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coactosin-like F-actin binding protein 1
|
| Other Description |
coactosin-like 1|coactosin-like protein
|
| Swissprots |
D3DUL9 Q14019 B2RDU3 Q86XM5
|
| Accessions |
EAW95475 EAW95476 EAW95477 Q14019 AK026033 AK093712 AK125645 AK127352 AK315675 BAG38040 BC010039 AAH10039 BC010884 AAH10884 BC016702 AAH16702 BC020445 BC042970 AAH42970 BC053682 AAH53682 BT006968 AAP35614 BX395081 DA968872 EU832743 ACE87075 JF432552 ADZ15769 L08436 L54057 AAA88022 NM_021149 NP_066972
|
| Function |
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269|PubMed:11583571, ECO:0000269|PubMed:19807693}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. {ECO:0000269|PubMed:11583571}.
|
![Western Blot: COTL1 Overexpression Lysate (Adult Normal) [NBL1-09402] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for COTL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8497_COTL1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09402-img0002.jpg)