Gene Symbol | COTL1 |
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Entrez Gene | 23406 |
Alt Symbol | CLP |
Species | Human |
Gene Type | protein-coding |
Description | coactosin-like F-actin binding protein 1 |
Other Description | coactosin-like 1|coactosin-like protein |
Swissprots | D3DUL9 Q14019 B2RDU3 Q86XM5 |
Accessions | EAW95475 EAW95476 EAW95477 Q14019 AK026033 AK093712 AK125645 AK127352 AK315675 BAG38040 BC010039 AAH10039 BC010884 AAH10884 BC016702 AAH16702 BC020445 BC042970 AAH42970 BC053682 AAH53682 BT006968 AAP35614 BX395081 DA968872 EU832743 ACE87075 JF432552 ADZ15769 L08436 L54057 AAA88022 NM_021149 NP_066972 |
Function | Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269|PubMed:11583571, ECO:0000269|PubMed:19807693}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus membrane; Peripheral membrane protein. |
Tissue Specificity | Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. {ECO:0000269|PubMed:11583571}. |
COTL1 CRISPR/Cas9 KO Plasmid (h) - sc-411734 from Santa Cruz Biotechnology
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COTL1 HDR Plasmid (h) - sc-411734-HDR from Santa Cruz Biotechnology
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COTL1 Double Nickase Plasmid (h) - sc-411734-NIC from Santa Cruz Biotechnology
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COTL1 Double Nickase Plasmid (h2) - sc-411734-NIC-2 from Santa Cruz Biotechnology
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COTL1 CRISPR Activation Plasmid (h) - sc-411734-ACT from Santa Cruz Biotechnology
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COTL1 CRISPR Activation Plasmid (h2) - sc-411734-ACT-2 from Santa Cruz Biotechnology
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COTL1 Lentiviral Activation Particles (h) - sc-411734-LAC from Santa Cruz Biotechnology
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COTL1 Lentiviral Activation Particles (h2) - sc-411734-LAC-2 from Santa Cruz Biotechnology
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COTL1 siRNA (h) - sc-93010 from Santa Cruz Biotechnology
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COTL1 shRNA Plasmid (h) - sc-93010-SH from Santa Cruz Biotechnology
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COTL1 shRNA (h) Lentiviral Particles - sc-93010-V from Santa Cruz Biotechnology
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Coactosin-like Protein 1/CotL1 RNAi - H00023406-R01 from Novus Biologicals
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MISSION® esiRNA - EHU029111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6461 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12588 from Sigma-Aldrich
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COTL1 siRNA (Human) - CRH8246 from Cohesion Biosciences
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COTL1 - MBS8207173 from MyBioSource
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shRNA set against Human COTL1 (NM_021149.2) - SHH268141 from Creative biogene
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Human COTL1 siRNA - orb268748 from Biorbyt
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COTL1 shRNA Plasmid (Human) - CHH8246 from Cohesion Biosciences
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COTL1 miRNA 3'UTR clone - MiUTR1H-02371 from Creative biogene
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