COTL1

Gene Symbol COTL1
Entrez Gene 23406
Alt Symbol CLP
Species Human
Gene Type protein-coding
Description coactosin-like F-actin binding protein 1
Other Description coactosin-like 1|coactosin-like protein
Swissprots D3DUL9 Q14019 B2RDU3 Q86XM5
Accessions EAW95475 EAW95476 EAW95477 Q14019 AK026033 AK093712 AK125645 AK127352 AK315675 BAG38040 BC010039 AAH10039 BC010884 AAH10884 BC016702 AAH16702 BC020445 BC042970 AAH42970 BC053682 AAH53682 BT006968 AAP35614 BX395081 DA968872 EU832743 ACE87075 JF432552 ADZ15769 L08436 L54057 AAA88022 NM_021149 NP_066972
Function Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269|PubMed:11583571, ECO:0000269|PubMed:19807693}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus membrane; Peripheral membrane protein.
Tissue Specificity Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. {ECO:0000269|PubMed:11583571}.

COTL1 CRISPR/Cas9 KO Plasmid (h) - sc-411734 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COTL1 HDR Plasmid (h) - sc-411734-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COTL1 Double Nickase Plasmid (h) - sc-411734-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COTL1 Double Nickase Plasmid (h2) - sc-411734-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COTL1 CRISPR Activation Plasmid (h) - sc-411734-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COTL1 CRISPR Activation Plasmid (h2) - sc-411734-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COTL1 Lentiviral Activation Particles (h) - sc-411734-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COTL1 Lentiviral Activation Particles (h2) - sc-411734-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COTL1 siRNA (h) - sc-93010 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COTL1 shRNA Plasmid (h) - sc-93010-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COTL1 shRNA (h) Lentiviral Particles - sc-93010-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Coactosin-like Protein 1/CotL1 RNAi - H00023406-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU029111 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6461 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6461 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12588 from Sigma-Aldrich

Category miRNA

COTL1 siRNA (Human) - CRH8246 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COTL1 - MBS8207173 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COTL1 (NM_021149.2) - SHH268141 from Creative biogene

Category siRNA
Species Reactivities Human

Human COTL1 siRNA - orb268748 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COTL1 shRNA Plasmid (Human) - CHH8246 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COTL1 miRNA 3'UTR clone - MiUTR1H-02371 from Creative biogene

Species Reactivities Human
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