COTL1

Gene Symbol COTL1
Entrez Gene 23406
Alt Symbol CLP
Species Human
Gene Type protein-coding
Description coactosin-like F-actin binding protein 1
Other Description coactosin-like 1|coactosin-like protein
Swissprots D3DUL9 Q14019 B2RDU3 Q86XM5
Accessions EAW95475 EAW95476 EAW95477 Q14019 AK026033 AK093712 AK125645 AK127352 AK315675 BAG38040 BC010039 AAH10039 BC010884 AAH10884 BC016702 AAH16702 BC020445 BC042970 AAH42970 BC053682 AAH53682 BT006968 AAP35614 BX395081 DA968872 EU832743 ACE87075 JF432552 ADZ15769 L08436 L54057 AAA88022 NM_021149 NP_066972
Function Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269|PubMed:11583571, ECO:0000269|PubMed:19807693}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus membrane; Peripheral membrane protein.
Tissue Specificity Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. {ECO:0000269|PubMed:11583571}.

COTL1 (F-12) - sc-160246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

COTL1 (T-12) - sc-160247 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-COTL1 antibody - ab93427 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-COTL1 antibody (ab93427) at 1/100 dilution + Hela cell line lysates at 35 µg

Anti-COTL1 antibody [AT1D6] - ab187608 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT1D6
Anti-COTL1 antibody [AT1D6] (ab187608) at 1/1000 dilution + SW480 cell lysate at 40 µgSecondarygoat anti-mouse secondary antibody conjugated to HRPdeveloped using the ECL technique

Anti-CLP / COTL1 Antibody (aa65-79) - LS-C190693 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (aa113-142, AP) - LS-C206501 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (aa113-142, APC) - LS-C206502 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (aa113-142, Biotin) - LS-C206503 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (N-Terminus) - LS-C107904 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
COTL1 antibody LS-C107904 Western blot of Fetal Thymus lysate.

Anti-CLP / COTL1 Antibody (aa113-142, FITC) - LS-C206504 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (aa113-142, Azide-free, HRP) - LS-C207960 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (Biotin) - LS-C318353 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody - LS-C318657 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (HRP) - LS-C318658 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (FITC) - LS-C318660 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (aa113-142) - LS-C327107 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLP / COTL1 Antibody (clone 5C8E3) - LS-C169157 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C8E3
Western blot using COTL1 monoclonal antibody against HEK293 (1) and COTL1 (AA: 1-142)-hIgGFc transfected HEK293 (2) cell lysate.

Anti-CLP / COTL1 Antibody (clone 5C8) - LS-C169468 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C8
IHC of paraffin-embedded breast cancer tissues using COTL1 mouse monoclonal antibody with DAB staining.

Anti-CLP / COTL1 Antibody (aa113-142) - LS-C166960 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human spleen tissue reacted with COTL1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CLP / COTL1 Antibody (aa113-142, PE) - LS-C206506 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Coactosin-like Protein 1/CotL1 Antibody - NBP1-54851 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Coactosin-like Protein 1/CotL1 Antibody [NBP1-54851] - Analysis of HeLa cell lysate (30ug) using anti-COTL1 antibody. Image from verified customer review.

Coactosin-like Protein 1/CotL1 Antibody - AF7865 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of JAR human choriocarcinoma cell line, NCI‑H345 human small cell lung carcinoma cell line, human placenta tissue, and rat placenta tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human/Mouse/Rat Coactosin-like Protein 1/COTL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7865) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Coactosin-like Protein 1/COTL1 at approximately 15 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Coactosin-like Protein 1/CotL1 Antibody (5C8) - NBP2-37519 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C8
Western Blot: Coactosin-like Protein 1/CotL1 Antibody (5C8) [NBP2-37519] - Western blot analysis using COTL1 mAb against HEK293 (1) and COTL1 (AA: 1-142)-hIgGFc transfected HEK293 (2) cell lysate.

Coactosin-like Protein 1/CotL1 Antibody (5C8E3) - NBP2-37517 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C8E3

Coactosin-like Protein 1/CotL1 Antibody (1D6) - NBP2-31203 from Novus Biologicals

Prices $229.00, $279.00
Sizes 50 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D6
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