| Gene Symbol |
RGS17
|
| Entrez Gene |
26575
|
| Alt Symbol |
RGS-17, RGSZ2, hRGS17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
regulator of G-protein signaling 17
|
| Other Description |
-
|
| Swissprots |
Q8TD61 Q5TF49 Q9UJS8 Q9UGC6
|
| Accessions |
CAK32368 EAW47711 Q9UGC6 AA902430 AF202257 AAF08978 AF493938 AAM12652 BC013117 AAH13117 BT006997 AAP35643 CK902282 XM_011535752 XP_011534054 XM_011535753 XP_011534055 XM_011535754 XP_011534056 NM_012419 NP_036551
|
| Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes. {ECO:0000269|PubMed:15096504}.
|
![Western Blot: RGS17 Overexpression Lysate (Adult Normal) [NBL1-15323] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RGS17.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2250_RGS17%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15323-img0002.jpg)