Gene Symbol | RGS17 |
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Entrez Gene | 26575 |
Alt Symbol | RGS-17, RGSZ2, hRGS17 |
Species | Human |
Gene Type | protein-coding |
Description | regulator of G-protein signaling 17 |
Other Description | - |
Swissprots | Q8TD61 Q5TF49 Q9UJS8 Q9UGC6 |
Accessions | CAK32368 EAW47711 Q9UGC6 AA902430 AF202257 AAF08978 AF493938 AAM12652 BC013117 AAH13117 BT006997 AAP35643 CK902282 XM_011535752 XP_011534054 XM_011535753 XP_011534055 XM_011535754 XP_011534056 NM_012419 NP_036551 |
Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation (By similarity). {ECO:0000250}. |
Tissue Specificity | Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes. {ECO:0000269|PubMed:15096504}. |
RGS17 CRISPR/Cas9 KO Plasmid (h) - sc-416360 from Santa Cruz Biotechnology
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RGS17 HDR Plasmid (h) - sc-416360-HDR from Santa Cruz Biotechnology
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RGS17 Double Nickase Plasmid (h) - sc-416360-NIC from Santa Cruz Biotechnology
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RGS17 Double Nickase Plasmid (h2) - sc-416360-NIC-2 from Santa Cruz Biotechnology
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RGS17 CRISPR Activation Plasmid (h) - sc-416360-ACT from Santa Cruz Biotechnology
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RGS17 CRISPR Activation Plasmid (h2) - sc-416360-ACT-2 from Santa Cruz Biotechnology
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RGS17 Lentiviral Activation Particles (h) - sc-416360-LAC from Santa Cruz Biotechnology
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RGS17 Lentiviral Activation Particles (h2) - sc-416360-LAC-2 from Santa Cruz Biotechnology
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RGS17 siRNA (h) - sc-61466 from Santa Cruz Biotechnology
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RGS17 shRNA Plasmid (h) - sc-61466-SH from Santa Cruz Biotechnology
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RGS17 shRNA (h) Lentiviral Particles - sc-61466-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU050651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18221 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05704 from Sigma-Aldrich
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RGS17 siRNA (Human) - CRH8861 from Cohesion Biosciences
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RGS17 RNAi - H00026575-R01 from Novus Biologicals
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RGS17 - MBS8215907 from MyBioSource
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shRNA set against Human RGS17 (NM_012419.4) - SHH394888 from Creative biogene
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Human RGS17 siRNA - orb269363 from Biorbyt
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RGS17 shRNA Plasmid (Human) - CHH8861 from Cohesion Biosciences
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RGS17 miRNA 3'UTR clone - MiUTR1H-08786 from Creative biogene
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