RBM8A

Gene Symbol RBM8A
Entrez Gene 9939
Alt Symbol BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1
Species Human
Gene Type protein-coding
Description RNA binding motif protein 8A
Other Description BOV-1|RNA binding motif protein 8B|RNA-binding motif protein 8A|RNA-binding protein 8A|RNA-binding protein Y14|binder of OVCA1-1|ribonucleoprotein RBM8|ribonucleoprotein RBM8A
Swissprots Q9GZX8 Q6IQ40 Q9NZI4 Q6FHD1 B3KQI9 Q9Y5S9
Accessions AAL26999 AIB06357 AIB06358 AIB06359 CAF86870 EAW71418 EAW71419 Q9Y5S9 AF127761 AAD21089 AF161463 AAF29078 AF182415 AAG14951 AF198620 AAF37551 AF231511 AAG16781 AF299118 AAG27091 AI424454 AK075009 BAG52051 AL049219 BC017088 AAH17088 BC017770 AAH17770 BC071577 CR541805 CAG46604 CR541823 CAG46622 DB286556 GQ129283 ACT64417 GQ129284 ACT64418 KF051020 AHX83806 NM_005105 NP_005096
Function Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and transla
Subcellular Location Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
Tissue Specificity Ubiquitous.
Top Pathways Spliceosome, RNA transport, mRNA surveillance pathway

RNA binding motif protein 8A, ELISA Kit - MBS9332300 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for RNA Binding Motif Protein 8 (RBM8) - SEG651Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for RNA Binding Motif Protein 8 (RBM8) - SEG651Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human RBM8 ELISA Kit - E033892 from Biobool

Category ELISA Kit
Sensitivity 0.063ng/mL.

Human RBM8A ELISA Kit - E033893 from Biobool

Category ELISA Kit

Human RNA-binding protein 8A (RBM8A) ELISA Kit - AE22695HU from ARP American Research Products

Category ELISA Kit
Prices $549.00
Sizes 96 t
Sensitivity 0.063 ng/mL
Range 0.156-10 ng/mL

RNA Binding Motif Protein 8, ELISA Kit - MBS2031876 from MyBioSource

Category ELISA Kit
Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.063ng/mL.
Range 0.156-10ng/mL. The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL, 0.156ng/mL.
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