RBM8A

Gene Symbol	RBM8A
Entrez Gene	9939
Alt Symbol	BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1
Species	Human
Gene Type	protein-coding
Description	RNA binding motif protein 8A
Other Description	BOV-1|RNA binding motif protein 8B|RNA-binding motif protein 8A|RNA-binding protein 8A|RNA-binding protein Y14|binder of OVCA1-1|ribonucleoprotein RBM8|ribonucleoprotein RBM8A
Swissprots	Q9GZX8 Q6IQ40 Q9NZI4 Q6FHD1 B3KQI9 Q9Y5S9
Accessions	AAL26999 AIB06357 AIB06358 AIB06359 CAF86870 EAW71418 EAW71419 Q9Y5S9 AF127761 AAD21089 AF161463 AAF29078 AF182415 AAG14951 AF198620 AAF37551 AF231511 AAG16781 AF299118 AAG27091 AI424454 AK075009 BAG52051 AL049219 BC017088 AAH17088 BC017770 AAH17770 BC071577 CR541805 CAG46604 CR541823 CAG46622 DB286556 GQ129283 ACT64417 GQ129284 ACT64418 KF051020 AHX83806 NM_005105 NP_005096
Function	Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and transla
Subcellular Location	Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
Tissue Specificity	Ubiquitous.
Top Pathways	Spliceosome, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Y14 full length protein - ab105606 from Abcam Category Protein Source E. coli Species Human

RBM8A Recombinant Protein - H00009939-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RBM8A Recombinant Protein - H00009939-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RBM8A Protein - NBP1-51060 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

RBM8A Protein (OPPA00186) - OPPA00186 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Escherichia Coli.

Human RBM8A protein - orb169171 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

RBM8A Blocking Peptide - 33R-5009 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RBM8A protein (His tag) - 80R-1748 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

RBM8A / RBM8 (1-174, His-tag) - AR09930PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

RBM8A / RBM8 (1-174, His-tag) - AR09930PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

RBM8A / RBM8 - H00009939-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RBM8A / RBM8 - H00009939-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RBM8A / RBM8 - H00009939-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

RBM8A / RBM8 - H00009939-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RBM8A / RBM8 - H00009939-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RBM8A, 1-174aa, Human, His tag, E.coli - 01-P0990 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

RBM8A,Y14 fusion protein - ag2935 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RBM8A,Y14 fusion protein - ag6800 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

RBM8A Human - PRPS-193 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant human RBM8A Protein - BP003000-PRO-186 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

RBM8A, 1-174aa, Recombinant Protein - GWB-P1048H from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

RBM8A Human Protein - GWB-BSP604 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human RBM8A, His-tagged - RBM8A-3493H from Creative Biomart Category Protein

Recombinant Human RBM8A, His-tagged - RBM8A-30135TH from Creative Biomart Category Protein Source E. coli

RBM8A - NKX-542 from Reagent Proteins Category Protein Prices $364.00, $5,334.00 Sizes 10.00 µg, 1 mg Source E.coli

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