RBM8A

Gene Symbol	RBM8A
Entrez Gene	9939
Alt Symbol	BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1
Species	Human
Gene Type	protein-coding
Description	RNA binding motif protein 8A
Other Description	BOV-1|RNA binding motif protein 8B|RNA-binding motif protein 8A|RNA-binding protein 8A|RNA-binding protein Y14|binder of OVCA1-1|ribonucleoprotein RBM8|ribonucleoprotein RBM8A
Swissprots	Q9GZX8 Q6IQ40 Q9NZI4 Q6FHD1 B3KQI9 Q9Y5S9
Accessions	AAL26999 AIB06357 AIB06358 AIB06359 CAF86870 EAW71418 EAW71419 Q9Y5S9 AF127761 AAD21089 AF161463 AAF29078 AF182415 AAG14951 AF198620 AAF37551 AF231511 AAG16781 AF299118 AAG27091 AI424454 AK075009 BAG52051 AL049219 BC017088 AAH17088 BC017770 AAH17770 BC071577 CR541805 CAG46604 CR541823 CAG46622 DB286556 GQ129283 ACT64417 GQ129284 ACT64418 KF051020 AHX83806 NM_005105 NP_005096
Function	Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and transla
Subcellular Location	Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
Tissue Specificity	Ubiquitous.
Top Pathways	Spliceosome, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Y14 CRISPR/Cas9 KO Plasmid (h) - sc-403255 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Y14 HDR Plasmid (h) - sc-403255-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Y14 Double Nickase Plasmid (h) - sc-403255-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Y14 Double Nickase Plasmid (h2) - sc-403255-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Y14 CRISPR Activation Plasmid (h) - sc-403255-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Y14 CRISPR Activation Plasmid (h2) - sc-403255-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Y14 Lentiviral Activation Particles (h) - sc-403255-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Y14 Lentiviral Activation Particles (h2) - sc-403255-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Y14 siRNA (h) - sc-38345 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Y14 shRNA Plasmid (h) - sc-38345-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Y14 shRNA (h) Lentiviral Particles - sc-38345-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RBM8A RNAi - H00009939-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU144511 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18057 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18057 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11270 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11270

RBM8A siRNA (Human) - CRH6681 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RBM8A - MBS8200567 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RBM8A (NM_005105.3) - SHH390908 from Creative biogene Category siRNA Species Reactivities Human

Human RBM8A siRNA - orb267183 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RBM8A shRNA Plasmid (Human) - CHH6681 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RBM8A miRNA 3'UTR clone - MiUTR4H-TG07371 from Creative biogene Species Reactivities Human

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