| Gene Symbol |
RBM8A
|
| Entrez Gene |
9939
|
| Alt Symbol |
BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA binding motif protein 8A
|
| Other Description |
BOV-1|RNA binding motif protein 8B|RNA-binding motif protein 8A|RNA-binding protein 8A|RNA-binding protein Y14|binder of OVCA1-1|ribonucleoprotein RBM8|ribonucleoprotein RBM8A
|
| Swissprots |
Q9GZX8 Q6IQ40 Q9NZI4 Q6FHD1 B3KQI9 Q9Y5S9
|
| Accessions |
AAL26999 AIB06357 AIB06358 AIB06359 CAF86870 EAW71418 EAW71419 Q9Y5S9 AF127761 AAD21089 AF161463 AAF29078 AF182415 AAG14951 AF198620 AAF37551 AF231511 AAG16781 AF299118 AAG27091 AI424454 AK075009 BAG52051 AL049219 BC017088 AAH17088 BC017770 AAH17770 BC071577 CR541805 CAG46604 CR541823 CAG46622 DB286556 GQ129283 ACT64417 GQ129284 ACT64418 KF051020 AHX83806 NM_005105 NP_005096
|
| Function |
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and transla
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Spliceosome, RNA transport, mRNA surveillance pathway
|
![Western Blot: RBM8A Overexpression Lysate (Adult Normal) [NBL1-15217] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RBM8A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6701_RBM8A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15217-img0002.jpg)