| Gene Symbol |
UBASH3A
|
| Entrez Gene |
53347
|
| Alt Symbol |
CLIP4, STS-2, TULA, TULA-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin associated and SH3 domain containing A
|
| Other Description |
T-cell ubiquitin ligand 1|T-cell ubiquitin ligand protein|cbl-interacting protein 4|suppressor of T-cell receptor signaling 2|ubiquitin-associated and SH3 domain-containing protein A
|
| Swissprots |
Q6ISK3 G5E9E4 Q6ISI6 Q6ISS9 P57075 Q6HA35 Q6HA34
|
| Accessions |
CAH05300 EAX09560 EAX09561 EAX09562 EAX09563 P57075 AA707211 AF520809 AAP80731 AF521702 AAP80738 AJ277750 CAB91543 AK301279 BAG62839 AK308151 AK313367 BC028138 AAH28138 BC069357 AAH69357 BC069483 AAH69483 BC069511 AAH69511 BC069577 DA926085 XM_006724013 XP_006724076 XM_011529605 XP_011527907 XM_011529606 XP_011527908 XM_011529607 XP_011527909 XM_011529608 XP_011527910 XM_011529609 XP_011527911 XM_011529610 XP_011527912 XR_244316 XR_937510 NM_001001895 NP_001001895 NM_001243467 NP_001230396 NM_018961 NP_061834
|
| Function |
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318, ECO:0000269|PubMed:18189269}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow. {ECO:0000269|PubMed:11281453, ECO:0000269|PubMed:15107835}.
|